MedKoo Cat#: 150077 | Name: Fusaric Acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fusaric acid is one of the most harmful phytotoxins produced in various plant-pathogen interactions. Fusaric acid is a potent inhibitor of DNA synthesis. Fusaric acid has potent anti-proliferative activity in vitro on various normal and cancer cell lines and suggest that it exhibits some cytotoxic specificity for growing and confluent colorectal adenocarcinoma and mammary adenocarcinoma cell lines.

Chemical Structure

Fusaric Acid
Fusaric Acid
CAS#536-69-6

Theoretical Analysis

MedKoo Cat#: 150077

Name: Fusaric Acid

CAS#: 536-69-6

Chemical Formula: C10H13NO2

Exact Mass: 179.0950

Molecular Weight: 179.22

Elemental Analysis: C, 67.02; H, 7.31; N, 7.82; O, 17.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
fusaric acid; 5-Butylpicolinic acid;
IUPAC/Chemical Name
5-butylpyridine-2-carboxylic acid
InChi Key
DGMPVYSXXIOGJY-UHFFFAOYSA-N
InChi Code
1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13)
SMILES Code
O=C(C1=NC=C(CCCC)C=C1)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 179.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Iqbal N, Czékus Z, Ördög A, Poór P. Fusaric acid-evoked oxidative stress affects plant defence system by inducing biochemical changes at subcellular level. Plant Cell Rep. 2023 Dec 18;43(1):2. doi: 10.1007/s00299-023-03084-9. PMID: 38108938; PMCID: PMC10728271. 2: Gulbay G, Secme M, Mutlu D. Fusaric acid inhibits cell proliferation and downregulates expressions of toll-like receptors pathway genes in Ishikawa endometrial cancer cells. Eur Rev Med Pharmacol Sci. 2023 Aug;27(16):7431-7436. doi: 10.26355/eurrev_202308_33394. PMID: 37667919. 3: Kuang Y, Scherlach K, Hertweck C, Yang S, Sampietro DA, Karlovsky P. Fusaric acid detoxification: a strategy of Gliocladium roseum involved in its antagonism against Fusarium verticillioides. Mycotoxin Res. 2022 Feb;38(1):13-25. doi: 10.1007/s12550-021-00448-6. Epub 2022 Jan 13. Retraction in: Mycotoxin Res. 2023 Aug;39(3):317. doi: 10.1007/s12550-023-00481-7. PMID: 35023019. 4: Ghazi T, Nagiah S, Chuturgoon AA. Fusaric acid induces hepatic global m6A RNA methylation and differential expression of m6A regulatory genes in vivo - a pilot study. Epigenetics. 2022 Jun;17(6):695-703. doi: 10.1080/15592294.2021.1975937. Epub 2021 Sep 13. PMID: 34517792; PMCID: PMC9235881. 5: Ghazi T, Nagiah S, Dhani S, Chuturgoon AA. Fusaric acid-induced epigenetic modulation of hepatic H3K9me3 triggers apoptosis in vitro and in vivo. Epigenomics. 2020 Jun;12(11):955-972. doi: 10.2217/epi-2019-0284. Epub 2020 Aug 7. PMID: 32762452.