Suillin | CAS#103538-03-0 | ethyl acetate

MedKoo Cat#: 145261 | Name: Suillin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Suillin is an ethyl acetate extract of the mushroom Suillus placidus. Suillin was found for the first time to induce apoptosis in HepG2 cells as characterized by DNA fragmentation. Suillin might be an effective agent to treat liver cancer. Suillin has high cytotoxic and antitumor properties.

Chemical Structure

Suillin

CAS#103538-03-0

Theoretical Analysis

MedKoo Cat#: 145261

Name: Suillin

CAS#: 103538-03-0

Chemical Formula: C28H40O4

Exact Mass: 440.2927

Molecular Weight: 440.62

Elemental Analysis: C, 64.55; H, 9.15; O, 14.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Suillin; NSC-625110;

IUPAC/Chemical Name

3,4-dihydroxy-2-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)phenyl acetate

InChi Key

TVYGOMSIBBSIKO-MLAGYPMBSA-N

InChi Code

1S/C28H40O4/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-15-23(5)16-17-25-27(32-24(6)29)19-18-26(30)28(25)31/h10,12,14,16,18-19,30-31H,7-9,11,13,15,17H2,1-6H3/b21-12+,22-14+,23-16+

SMILES Code

CC(=O)OC1=CC=C(O)C(O)=C1C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 440.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Andrade JM, Pachar P, Trujillo L, Cartuche L. Suillin: A mixed-type acetylcholinesterase inhibitor from Suillus luteus which is used by Saraguros indigenous, southern Ecuador. PLoS One. 2022 May 16;17(5):e0268292. doi: 10.1371/journal.pone.0268292. PMID: 35576219; PMCID: PMC9109927. 2: Yan Y, Yao S, Jia Z, Zhao J, Wang L. Iso-suillin-induced DNA damage leading to cell cycle arrest and apoptosis arised from p53 phosphorylation in A549 cells. Eur J Pharmacol. 2021 Sep 15;907:174299. doi: 10.1016/j.ejphar.2021.174299. Epub 2021 Jul 1. PMID: 34217708. 3: Wang Y, Zhang Q, Zhao J, Zhao X, Zhang J, Wang LA. Iso-suillin from the mushroom Suillus flavus induces cell cycle arrest and apoptosis in K562 cell line. Food Chem Toxicol. 2014 May;67:17-25. doi: 10.1016/j.fct.2014.02.007. Epub 2014 Feb 14. PMID: 24534064. 4: Liu FY, Luo KW, Yu ZM, Co NN, Wu SH, Wu P, Fung KP, Kwok TT. Suillin from the mushroom Suillus placidus as potent apoptosis inducer in human hepatoma HepG2 cells. Chem Biol Interact. 2009 Oct 7;181(2):168-74. doi: 10.1016/j.cbi.2009.07.008. Epub 2009 Jul 17. PMID: 19616521. 5: Zhao JX, Zhang QS, Chen Y, Yao SJ, Yan YX, Wang Y, Zhang JX, Wang LA. Iso- suillin from Suillus flavus Induces Apoptosis in Human Small Cell Lung Cancer H446 Cell Line. Chin Med J (Engl). 2016 May 20;129(10):1215-23. doi: 10.4103/0366-6999.181961. PMID: 27174331; PMCID: PMC4878168. 6: Jia ZQ, Chen Y, Yan YX, Zhao JX. Iso-suillin isolated from Suillus luteus, induces G1 phase arrest and apoptosis in human hepatoma SMMC-7721 cells. Asian Pac J Cancer Prev. 2014;15(3):1423-8. doi: 10.7314/apjcp.2014.15.3.1423. PMID: 24606477. 7: Geraci C, Piattelli M, Tringali C, Verbist JF, Roussakis C. Cytotoxic activity of tetraprenylphenols related to suillin, an antitumor principle from Suillus granulatus. J Nat Prod. 1992 Dec;55(12):1772-5. doi: 10.1021/np50090a010. PMID: 1294697. 8: Zhao H, Xiong M, Yang X, Yao L, Li Z, Zhang J, Lv J. Isolation and target identification of antihepatoma polyprenylphenols from the edible mushroom Suillus granulatus. Food Funct. 2024 Jun 21. doi: 10.1039/d4fo01500b. Epub ahead of print. PMID: 38904163. 9: León F, Brouard I, Torres F, Quintana J, Rivera A, Estévez F, Bermejo J. A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells. Chem Biodivers. 2008 Jan;5(1):120-5. doi: 10.1002/cbdv.200890002. PMID: 18205114. 10: Tringali C, Geraci C, Nicolosi G, Verbist JF, Roussakis C. An antitumor principle from Suillus granulatus. J Nat Prod. 1989 Jul-Aug;52(4):844-5. doi: 10.1021/np50064a030. PMID: 2809609. 11: Venditti A, Frezza C, Sciubba F, Serafini M, Bianco A. Primary and secondary metabolites of an European edible mushroom and its nutraceutical value: Suillus bellinii (Inzenga) Kuntze. Nat Prod Res. 2017 Aug;31(16):1910-1919. doi: 10.1080/14786419.2016.1267731. Epub 2016 Dec 26. PMID: 28013555. 12: Wu S, Yang L, Gao Y, Liu X, Liu F. Multi-channel counter-current chromatography for high-throughput fractionation of natural products for drug discovery. J Chromatogr A. 2008 Feb 8;1180(1-2):99-107. doi: 10.1016/j.chroma.2007.12.024. Epub 2007 Dec 31. PMID: 18166193.