DA-8031 | CAS#1148027-74-0 | serotonin reuptake inhibitor

MedKoo Cat#: 145255 | Name: DA-8031

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DA-8031 is a novel selective serotonin reuptake inhibitor for the treatment of premature ejaculation.

Chemical Structure

DA-8031

CAS#1148027-74-0

Theoretical Analysis

MedKoo Cat#: 145255

Name: DA-8031

CAS#: 1148027-74-0

Chemical Formula: C21H24N2O2

Exact Mass: 336.1838

Molecular Weight: 336.44

Elemental Analysis: C, 74.97; H, 7.19; N, 8.33; O, 9.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DA-8031; DA8031; DA 8031;

IUPAC/Chemical Name

1-(3-(dimethylamino)propyl)-1-(4-methoxyphenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

InChi Key

RCMIUWUYNFSCAE-UHFFFAOYSA-N

InChi Code

1S/C21H24N2O2/c1-23(2)12-4-11-21(18-6-8-19(24-3)9-7-18)20-10-5-16(14-22)13-17(20)15-25-21/h5-10,13H,4,11-12,15H2,1-3H3

SMILES Code

COC1=CC=C(C=C1)C2(CCCN(C)C)OCC3=CC(=CC=C23)C#N

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hwang S, Lee DY, Cho JY, Chung JY, Jang IJ, Yu KS, Lee S. Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects. Drug Des Devel Ther. 2021 Jun 1;15:2375-2384. doi: 10.2147/DDDT.S309763. PMID: 34103898; PMCID: PMC8179755. 2: Kang KK, Sung JH, Kim SH, Lee S. Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior. Int J Urol. 2014 Mar;21(3):325-9. doi: 10.1111/iju.12256. Epub 2013 Aug 22. PMID: 23968141. 3: Shin D, Lee S, Yi S, Yoon SH, Cho JY, Bahng MY, Jang IJ, Yu KS. Pharmacokinetics and tolerability of DA-8031, a novel selective serotonin reuptake inhibitor for premature ejaculation in healthy male subjects. Drug Des Devel Ther. 2017 Mar 10;11:713-723. doi: 10.2147/DDDT.S126861. PMID: 28331291; PMCID: PMC5354528. 4: Jeon HJ, Kim HS, Lee CH, Lee YG, Choi SM, Sohn YS, Shin CY, Kim J, Shim HJ, Kang KK, Ahn BO, Kim SH. Candidate molecule for premature ejaculation, DA-8031: in vivo and in vitro characterization of DA-8031. Urology. 2011 Apr;77(4):1006.e17-21. doi: 10.1016/j.urology.2010.11.046. Epub 2011 Jan 22. PMID: 21256578. 5: Kang KK, Ahn GJ, Sung JH, Kim SH, Kim H, Lee S. Ejaculatory responses are inhibited by a new chemical entity, DA-8031, in preclinical rodent models of ejaculation. Urology. 2013 Apr;81(4):920.e13-8. doi: 10.1016/j.urology.2012.12.006. Epub 2013 Feb 8. PMID: 23394880. 6: Park HS, Jung IS, Lim NH, Sung JH, Lee S, Moon BS, Lee BC, Kang KK, Kim SE. Proof of mechanism study of a novel serotonin transporter blocker, DA-8031, using [11C]DASB positron emission tomography and in vivo microdialysis. Urology. 2014 Jul;84(1):245.e1-7. doi: 10.1016/j.urology.2014.03.014. Epub 2014 May 10. PMID: 24824409. 7: Simões Paço J, Jorge Pereira B. New Therapeutic Perspectives in Premature Ejaculation. Urology. 2016 Feb;88:87-92. doi: 10.1016/j.urology.2015.11.003. Epub 2015 Nov 25. PMID: 26627373.