Synonym
GA-0113; GA0113; GA 0113;
IUPAC/Chemical Name
8-(3,4-dihydroxy-4-methylpentyl)-3-isopropyl-7-methylnaphthalene-1,2-dione
InChi Key
GDHVAFNGEXASMP-UHFFFAOYSA-N
InChi Code
1S/C27H24F3N5O2S/c1-4-24-33-25-16(2)13-17(3)31-26(25)35(24)15-18-9-11-21-19(14-18)10-12-22(32-21)20-7-5-6-8-23(20)34-38(36,37)27(28,29)30/h5-14,34H,4,15H2,1-3H3
SMILES Code
CCC1=NC2=C(C)C=C(C)N=C2N1CC3=CC=C4N=C(C=CC4=C3)C5=CC=CC=C5NS(=O)(=O)C(F)(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
330.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Matsumoto K, Morishita R, Tomita N, Moriguchi A, Komai N, Aoki M, Matsumoto K, Nakamura T, Higaki J, Ogihara T. Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats. Heart Vessels. 2003 Mar;18(1):18-25. doi: 10.1007/s003800300003. PMID: 12644877.
3: Ebisu H, Nishikawa M, Tanaka M, Okazoe T, Morizawa Y, Shinyama H, Nakamura N. Pharmacologic profiles of GA0113, a novel quinoline derivative angiotensin II AT1-receptor antagonist. J Cardiovasc Pharmacol. 1999 Oct;34(4):526-32. doi: 10.1097/00005344-199910000-00008. PMID: 10511127.
4: Enoch MA, Hodgkinson CA, Shen PH, Gorodetsky E, Marietta CA, Roy A, Goldman D. GABBR1 and SLC6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations. Alcohol Clin Exp Res. 2016 Jan;40(1):93-101. doi: 10.1111/acer.12929. PMID: 26727527; PMCID: PMC4700558.
