XRD-0394 is a DNA-PKcs inhibitor. XRD-0394 selectively targets, binds to and inhibits the activity of ATM and DNA-PK. This inhibits ATM-mediated signaling, which may prevent DNA damage checkpoint activation, disrupt DNA damage repair and induce tumor cell apoptosis. XRD-0394 demonstrates significantly enhanced tumor cell kill in the setting of therapeutic ionizing irradiation in vitro and in vivo. XRD-0394 also potentiates the effectiveness of topoisomerase I inhibitors in vitro. In addition, in cells lacking BRCA1/2 XRD-0394 shows single-agent activity and synergy in combination with PARP inhibitors
MedKoo Cat#: 127338
Name: XRD-0394
CAS#: 2595308-10-2
Chemical Formula: C26H30FN5O4S
Exact Mass: 527.2003
Molecular Weight: 527.62
Elemental Analysis: C, 59.19; H, 5.73; F, 3.60; N, 13.27; O, 12.13; S, 6.08
The following data is based on the product molecular weight 527.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
