PA8 is a PD-L1 inhibitor. PA8 showed activity for PD-L1 degradation in 4T1 cells (DC50 = 0.609 μM). Significantly, PA8 potentially inhibits 4T1 cell growth both in vitro and in vivo. Further mechanistic studies revealed that PA8 effectively promoted the immune activation of model mice. PA8 could be a novel strategy for cancer immunotherapy in the 4T1 tumor model. Although PA8 exhibits weaker degradation activity in some human cancer cells, it still provides a certain basis for further research on PD-L1 PROTAC
MedKoo Cat#: 127246
Name: PA8
CAS#: N/A
Chemical Formula: C45H55N5O7
Exact Mass: 777.4101
Molecular Weight: 777.96
Elemental Analysis: C, 69.48; H, 7.13; N, 9.00; O, 14.40
The following data is based on the product molecular weight 777.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
