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MedKoo Cat#: 145211 | Name: Sutetinib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sutetinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR). Sutetinib shows favorable efficacy and safety in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harbouring nondrug-resistant rare EGFR mutations.

Chemical Structure

Sutetinib
Sutetinib
CAS#1259519-20-4

Theoretical Analysis

MedKoo Cat#: 145211

Name: Sutetinib

CAS#: 1259519-20-4

Chemical Formula: C26H25N5O2

Exact Mass: 439.2008

Molecular Weight: 439.52

Elemental Analysis: C, 71.05; H, 5.73; N, 15.93; O, 7.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Sutetinib;
IUPAC/Chemical Name
(E)-N-(3-cyano-7-ethoxy-4-((3-ethynylphenyl)amino)quinolin-6-yl)-4-(dimethylamino)but-2-enamide
InChi Key
NAVJYTIRRMDRQK-DHZHZOJOSA-N
InChi Code
1S/C26H25N5O2/c1-5-18-9-7-10-20(13-18)29-26-19(16-27)17-28-22-15-24(33-6-2)23(14-21(22)26)30-25(32)11-8-12-31(3)4/h1,7-11,13-15,17H,6,12H2,2-4H3,(H,28,29)(H,30,32)/b11-8+
SMILES Code
CCOC1=C(NC(=O)\C=C\CN(C)C)C=C2C(=C1)N=CC(C#N)=C2NC3=CC(=CC=C3)C#C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 439.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qiu Y, Tang C, Li R, Cao S, Zhang Y, Chen X. Simultaneous determination of sutetinib and its active metabolite sutetinib N-oxide in human plasma by liquid chromatography-tandem mass spectrometry: Evaluation of plasma stability. Biomed Chromatogr. 2020 Oct;34(10):e4918. doi: 10.1002/bmc.4918. Epub 2020 Aug 13. PMID: 32533577. 2: Cao B, Ma T, Zhang Y, Huang L, Lin H, Jiang H, Zhao Y, Geng Y, Yang Y, Cao S, Li J. The effect of food on the pharmacokinetics of Sutetinib maleate capsule, an irreversible EGFR tyrosine kinase inhibitor, in healthy Chinese subjects. Invest New Drugs. 2024 Jun;42(3):289-298. doi: 10.1007/s10637-024-01436-0. Epub 2024 Apr 11. PMID: 38602625.