AF-45 is an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury. AF-45 was found to block the NF-κB/MAPK pathway and target IRAK4, a promising target for inflammation and autoimmune diseases. In vivo, AF-45 exhibited a good therapeutic effect on UC and ALI, and favorable PK proprieties.
MedKoo Cat#: 127321
Name: AF-45
CAS#: N/A
Chemical Formula: C22H25N3O3
Exact Mass: 379.1896
Molecular Weight: 379.46
Elemental Analysis: C, 69.64; H, 6.64; N, 11.07; O, 12.65
The following data is based on the product molecular weight 379.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
