Synonym
FLT3 inhibitor 34f; FLT3=IN-34f; FLT3-IN-20; GTPL12911; GLXC-27656;
IUPAC/Chemical Name
N6-((1r,4r)-4-Aminocyclohexyl)-3-phenyl-N8-(4-(pyrrolidin-1-ylsulfonyl)phenyl)imidazo[1,2-b]pyridazine-6,8-diamine
InChi Key
IOMVZMIXBDMKIE-AFARHQOCSA-N
InChi Code
1S/C28H33N7O2S/c29-21-8-10-23(11-9-21)32-27-18-25(28-30-19-26(35(28)33-27)20-6-2-1-3-7-20)31-22-12-14-24(15-13-22)38(36,37)34-16-4-5-17-34/h1-3,6-7,12-15,18-19,21,23,31H,4-5,8-11,16-17,29H2,(H,32,33)/t21-,23-
SMILES Code
O=S(C1=CC=C(NC2=CC(N[C@H]3CC[C@H](N)CC3)=NN4C2=NC=C4C5=CC=CC=C5)C=C1)(N6CCCC6)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
531.68
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Břehová P, Řezníčková E, Škach K, Jorda R, Dejmek M, Vojáčková V, Šála M, Kovalová M, Dračínský M, Dolníková A, Strmeň T, Kinnertová M, Chalupský K, Dvořáková A, Gucký T, Mertlíková Kaiserová H, Klener P, Nencka R, Kryštof V. Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping. J Med Chem. 2023 Aug 24;66(16):11133-11157. doi: 10.1021/acs.jmedchem.3c00575. Epub 2023 Aug 3. PMID: 37535845; PMCID: PMC10461230.
