MedKoo Cat#: 150035 | Name: PMX Inhibitor 7k

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PMX Inhibitor 7k is a PMX inhibitor. Inhibitor 7k clears blood-stage P. falciparum in a dose-dependent manner when administered orally to infected humanized mice showing that 7k represents a promising orally bioavailable molecule for further development as a PMX-targeting antimalarial drug.

Chemical Structure

PMX Inhibitor 7k
PMX Inhibitor 7k
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 150035

Name: PMX Inhibitor 7k

CAS#: N/A

Chemical Formula: C36H47N3O4

Exact Mass: 585.3570

Molecular Weight: 585.79

Elemental Analysis: C, 73.81; H, 8.09; N, 7.17; O, 10.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
PMX Inhibitor 7k; PMX-IN-7k; PMX IN 7k; PMXIN7k; GLXC-27650; HY-155130;
IUPAC/Chemical Name
(S)-4-((R)-1-Hydroxy-2-((2-(3-methoxyphenyl)propan-2-yl)amino)ethyl)-12-propyl-3,12-diaza-1,6(1,3)-dibenzenacyclotridecaphane-2,13-dione
InChi Key
PYBIHWRQNXYDCA-JHOUSYSJSA-N
InChi Code
1S/C36H47N3O4/c1-5-19-39-20-8-6-7-12-26-13-9-14-27(21-26)22-32(38-34(41)28-15-10-16-29(23-28)35(39)42)33(40)25-37-36(2,3)30-17-11-18-31(24-30)43-4/h9-11,13-18,21,23-24,32-33,37,40H,5-8,12,19-20,22,25H2,1-4H3,(H,38,41)/t32-,33+/m0/s1
SMILES Code
O=C(N[C@H]([C@H](O)CNC(C)(C1=CC=CC(OC)=C1)C)CC2=CC=CC(CCCCCN(CCC)C3=O)=C2)C4=CC3=CC=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 585.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kovada V, Withers-Martinez C, Bobrovs R, Ce Rule HN, Liepins E, Grinberga S, Hackett F, Collins CR, Kreicberga A, Jiménez-Díaz MB, Angulo-Barturen I, Rasina D, Suna E, Jaudzems K, Blackman MJ, Jirgensons A. Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity. J Med Chem. 2023 Aug 10;66(15):10658-10680. doi: 10.1021/acs.jmedchem.3c00812. Epub 2023 Jul 28. PMID: 37505188; PMCID: PMC10424242.