CM-444 | CAS#unknown | Epigenetic Inhibitor

MedKoo Cat#: 464472 | Name: CM-444

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CM-444 is a Novel Epigenetic Inhibitor Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma.

Chemical Structure

CM-444

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464472

Name: CM-444

CAS#: unknown

Chemical Formula: C27H30N6O5

Exact Mass: 518.2278

Molecular Weight: 518.57

Elemental Analysis: C, 62.54; H, 5.83; N, 16.21; O, 15.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CM-444; CM444; CM 444;

IUPAC/Chemical Name

2-(4-(((6,7-dimethoxy-2-(5-methylfuran-2-yl)quinolin-4-yl)amino)methyl)piperidin-1-yl)-N-hydroxypyrimidine-5-carboxamide

InChi Key

DDJFEVNAMKGVES-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H30N6O5/c1-16-4-5-23(38-16)22-11-20(19-10-24(36-2)25(37-3)12-21(19)31-22)28-13-17-6-8-33(9-7-17)27-29-14-18(15-30-27)26(34)32-35/h4-5,10-12,14-15,17,35H,6-9,13H2,1-3H3,(H,28,31)(H,32,34)

SMILES Code

O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 518.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rabal O, San José-Enériz E, Agirre X, Sánchez-Arias JA, de Miguel I, Ordoñez R, Garate L, Miranda E, Sáez E, Vilas-Zornoza A, Pineda-Lucena A, Estella A, Zhang F, Wu W, Xu M, Prosper F, Oyarzabal J. Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma. J Med Chem. 2021 Mar 25;64(6):3392-3426. doi: 10.1021/acs.jmedchem.0c02255. Epub 2021 Mar 4. PMID: 33661013.