IUPAC/Chemical Name
3,5-Bis(4-chlorophenyl)-7-hydroxyisobenzofuran-1(3H)-one
InChi Key
ZGUNZGCMMQWFMG-UHFFFAOYSA-N
InChi Code
1S/C20H12Cl2O3/c21-14-5-1-11(2-6-14)13-9-16-18(17(23)10-13)20(24)25-19(16)12-3-7-15(22)8-4-12/h1-10,19,23H
SMILES Code
O=C1OC(C2=CC=C(Cl)C=C2)C3=C1C(O)=CC(C4=CC=C(Cl)C=C4)=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
371.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chowdhury, S.R., Godinho, J.L.P., Vinayagam, J. et al. Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites. Sci Rep 8, 11940 (2018). https://doi.org/10.1038/s41598-018-30405-w
2: Mishra A, Vinayagam J, Saha S, Chowdhury S, Chowdhury SR, Jaisankar P, Majumder HK. Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response. Pharmacol Res Perspect. 2014 Dec;2(6):e00070. doi: 10.1002/prp2.70. Epub 2014 Aug 24. Erratum in: Pharmacol Res Perspect. 2018 Sep 17;6(5):e00429. doi: 10.1002/prp2.429. PMID: 25505614; PMCID: PMC4186449.
1: Chowdhury, S.R., Godinho, J.L.P., Vinayagam, J. et al. Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites. Sci Rep 8, 11940 (2018). https://doi.org/10.1038/s41598-018-30405-w
