TAC-activator, also known as TAC, is a TERT activator compound (TAC). TAC could therapeutically restore the ‘youthful’ levels of a specific subunit of the telomerase enzyme, and could significantly reduce the signs and symptoms of aging in preclinical models. TAC improved neuromuscular function, coordination, grip strength and speed in these models, reversing sarcopenia – a condition under which muscle mass, strength and performance naturally worsen with advancing age. TAC treatment in human cell lines increased telomere synthesis with reduced DNA damage signal at telomeres and extended the proliferative potential of these cells, demonstrating the activity of TAC in ex vivo human models. TAC-activator may have therapeutic implications for age-related diseases such as Alzheimer’s, Parkinson’s, heart disease and cancer.
MedKoo Cat#: 556370
Name: TAC-activator
CAS#: 666699-46-3
Chemical Formula: C14H12ClF2NO2S
Exact Mass: 331.0245
Molecular Weight: 331.76
Elemental Analysis: C, 50.69; H, 3.65; Cl, 10.69; F, 11.45; N, 4.22; O, 9.64; S, 9.66
The following data is based on the product molecular weight 331.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
