Enrasentan, also known as SB-217242, is a dual receptor endothelin antagonist with a higher affinity for ET(A) receptors. In an animal model of hypertension and cardiac hypertrophy the drug has reduced blood pressure, prevented cardiac hypertrophy and preserved myocardial function. Enrasentan improves survival, limits left ventricular remodeling, and preserves myocardial performance in hypertensive cardiac hypertrophy and dysfunction.
MedKoo Cat#: 127245
Name: Enrasentan edamine
CAS#: 183507-63-3 (edamine)
Chemical Formula: C60H68N2O16
Exact Mass: 1072.4569
Molecular Weight: 1073.20
Elemental Analysis: C, 67.15; H, 6.39; N, 2.61; O, 23.85
The following data is based on the product molecular weight 1,073.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
