Fosmidomycin, also known as FR-31564, is a protein synthesis inhibitor potentially for the treatment of plasmodium falciparum malaria. Fosmidomycin is an antibiotic that was originally isolated from culture broths of bacteria of the genus Streptomyces. It specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM, MTB at 80 nM, and the Francisella enzyme at 99 nM.
MedKoo Cat#: 127229
Name: Fosmidomycin
CAS#: 66508-53-0 (free acid)
Chemical Formula: C4H10NO5P
Exact Mass: 183.0297
Molecular Weight: 183.10
Elemental Analysis: C, 26.24; H, 5.51; N, 7.65; O, 43.69; P, 16.92
The following data is based on the product molecular weight 183.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
