DS08701581 is a feline sarcoma-related tyrosine kinase inhibitor (IC50 = 1.9 nM). DS08701581 showed the highest class cell-free and cell activities in this template, good oral BA, and improved kinase selectivity, resulting in significant tumor growth inhibition in the Ba/F3-FER tumor model without body weight loss.
MedKoo Cat#: 127220
Name: DS08701581
CAS#: N/A
Chemical Formula: C26H32N8O2
Exact Mass: 488.2648
Molecular Weight: 488.60
Elemental Analysis: C, 63.91; H, 6.60; N, 22.93; O, 6.55
The following data is based on the product molecular weight 488.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
