KML-010 is a derivative of spiperone. KML-010 exhibits slightly lower affinity for 5-HT(2A) receptors compared to spiperone, but lacks affinity for 5-HT(2C) and 5-HT(1A) receptors, and showed significantly reduced affinity for dopamine D2 receptors. When the N(1)-phenyl ring of spiperone is modified to a methyl group in KML-010, its binding profile is altered, potentially offering a more selective pharmacological profile for targeting specific receptors.
MedKoo Cat#: 145115
Name: KML-010
CAS#: 217635-62-6
Chemical Formula: C18H24FN3O2
Exact Mass: 333.1853
Molecular Weight: 333.41
Elemental Analysis: C, 64.84; H, 7.26; F, 5.70; N, 12.60; O, 9.60
The following data is based on the product molecular weight 333.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
