G-15 | CAS#1161002-05-6 | Antagonist

MedKoo Cat#: 145085 | Name: G-15

Description:

WARNING: This product is for research use only, not for human or veterinary use.

G-15 is an antagonist of G-protein coupled estrogen receptor 1(GPER-1). G-15 significantly decreased nuclear volumes of HVC and Area X in male finches, as well as muscle fiber sizes in the syrinx, while in females, it increased muscle fiber sizes without affecting brain measures. The cAMP and phosphorylation of CREB are inhibited by G-15.

Chemical Structure

G-15

CAS#1161002-05-6

Theoretical Analysis

MedKoo Cat#: 145085

Name: G-15

CAS#: 1161002-05-6

Chemical Formula: C19H16BrNO2

Exact Mass: 369.0364

Molecular Weight: 370.25

Elemental Analysis: C, 61.64; H, 4.36; Br, 21.58; N, 3.78; O, 8.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

G-15; G15; G 15;

IUPAC/Chemical Name

(3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

InChi Key

YOLTZIVRJAPVPH-MJLGCCKJSA-N

InChi Code

1S/C19H16BrNO2/c20-15-9-18-17(22-10-23-18)8-14(15)19-13-6-3-5-11(13)12-4-1-2-7-16(12)21-19/h1-5,7-9,11,13,19,21H,6,10H2/t11-,13-,19+/m0/s1

SMILES Code

[H][C@]12CC=C[C@@]1([H])C3=CC=CC=C3N[C@H]2C4=C(Br)C=C5OCOC5=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Imesch P, Samartzis EP, Dedes KJ, Fink D, Fedier A. Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER- antagonist G-15 inhibits proliferation in endometriotic cells. Fertil Steril. 2013 Sep;100(3):770-6. doi: 10.1016/j.fertnstert.2013.05.008. Epub 2013 Jun 10. PMID: 23755949. 2: Gillingham KK, Fosdick JP. High-G training for fighter aircrew. Aviat Space Environ Med. 1988 Jan;59(1):12-9. PMID: 3355460. 3: He J, Zhao C, Guo Y, Zhang H, Zhao B, Chu Z. Completely mitochondrial genome of Neolissochilus heterostomus. Mitochondrial DNA B Resour. 2021 Aug 19;6(9):2708-2709. doi: 10.1080/23802359.2021.1945966. PMID: 34435128; PMCID: PMC8382013. 4: Gregson JM, Crain PF, Edmonds CG, Gupta R, Hashizume T, Phillipson DW, McCloskey JA. Structure of the archaeal transfer RNA nucleoside G*-15 (2-amino-4,7-dihydro- 4-oxo-7-beta-D- ribofuranosyl-1H-pyrrolo[2,3-d]pyrimidine-5-carboximi dam ide (archaeosine)). J Biol Chem. 1993 May 15;268(14):10076-86. PMID: 7683667. 5: Barreto CAV, Baptista SJ, Preto AJ, Silvério D, Melo R, Moreira IS. Decoding Partner Specificity of Opioid Receptor Family. Front Mol Biosci. 2021 Sep 21;8:715215. doi: 10.3389/fmolb.2021.715215. PMID: 34621786; PMCID: PMC8490921. 6: Garcia-Hidalgo C, Schmölzer GM. Chest Compressions in the Delivery Room. Children (Basel). 2019 Jan 3;6(1):4. doi: 10.3390/children6010004. PMID: 30609872; PMCID: PMC6352088. 7: Xie L, Fu L, Mei C, Wang Y, Chen M, Gu X. Icariin attenuates renal interstitial fibrosis through G protein-coupled estrogen receptor in a UUO murine model. Am J Transl Res. 2022 Mar 15;14(3):1567-1577. PMID: 35422936; PMCID: PMC8991158. 8: Tehrani MA, Veney SL. Intracranial administration of the G-protein coupled estrogen receptor 1 antagonist, G-15, selectively affects dimorphic characteristics of the song system in zebra finches (Taeniopygia guttata). Dev Neurobiol. 2018 Apr 20. doi: 10.1002/dneu.22599. Epub ahead of print. PMID: 29675990. 9: Chuang SC, Chen CH, Chou YS, Ho ML, Chang JK. G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells. Int J Mol Sci. 2020 Sep 5;21(18):6490. doi: 10.3390/ijms21186490. PMID: 32899453; PMCID: PMC7555423. 10: Pawlicki P, Duliban M, Tuz R, Ptak A, Milon A, Gorowska-Wojtowicz E, Tworzydlo W, Płachno BJ, Bilinska B, Knapczyk-Stwora K, Kotula-Balak M. Do G-protein coupled estrogen receptor and bisphenol A analogs influence on Leydig cell epigenetic regulation in immature boar testis ex vivo? Anim Reprod Sci. 2019 Aug;207:21-35. doi: 10.1016/j.anireprosci.2019.06.006. Epub 2019 Jun 6. PMID: 31266599. 11: Planisich A, Utsumi SA, Larripa M, Galli JR. Grazing of cover crops in integrated crop-livestock systems. Animal. 2021 Jan;15(1):100054. doi: 10.1016/j.animal.2020.100054. Epub 2020 Dec 10. PMID: 33516031. 12: Gillingham KK. G-tolerance standards for aircrew training and selection. Aviat Space Environ Med. 1987 Oct;58(10):1024-6. PMID: 3675463. 13: Meng F, Zhang L, Zhang W. Two forms of G protein-coupled estrogen receptor 1 in the ricefield eel: Expression and functional characterization in relation to ovarian follicle development. Gen Comp Endocrinol. 2021 Apr 1;304:113720. doi: 10.1016/j.ygcen.2021.113720. Epub 2021 Jan 27. PMID: 33508329. 14: Cheng Q, Meng J, Wang XS, Kang WB, Tian Z, Zhang K, Liu G, Zhao JN. G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice. Biosci Rep. 2016 Aug 31;36(4):e00373. doi: 10.1042/BSR20160134. PMID: 27407175; PMCID: PMC5006313. 15: Shin YS, Buehring KU, Stokstad EL. Separation of folic acid compounds by gel chromatography on Sephadex G-15 and G-25. J Biol Chem. 1972 Nov 25;247(22):7266-9. PMID: 4629400. 16: Kurt AH, Bosnak M, Inan SY, Celik A, Uremis MM. Epileptogenic effects of G protein-coupled estrogen receptor 1 in the rat pentylenetetrazole kindling model of epilepsy. Pharmacol Rep. 2016 Feb;68(1):66-70. doi: 10.1016/j.pharep.2015.07.001. Epub 2015 Jul 17. PMID: 26721354. 17: Moriya H, Yamazaki K, Fukushima H. Use of Sephadex G-10 and G-15 gel filtration for fractionation of a certain peptide. J Biochem. 1966 Aug;60(2):225-7. doi: 10.1093/oxfordjournals.jbchem.a128424. PMID: 5968968. 18: Abbas Z, Khan MK, Abbas RZ, Sindhu ZUD, Sajid MS, Munir A, Wahid A, Zafar A, Mughal MAS, Imran M, Mehmood R, Nadeem M. Molecular Epidemiology of Cryptosporidium parvum and Giardia lamblia in Different Water Bodies, Soil, and Vegetables in Pakistan. Health Secur. 2022 Jul- Aug;20(4):308-320. doi: 10.1089/hs.2021.0118. Epub 2022 Jul 20. PMID: 35861848. 19: Dinh QN, Vinh A, Kim HA, Saini N, Broughton BRS, Chrissobolis S, Diep H, Judkins CP, Drummond GR, Sobey CG. Aldosterone-induced hypertension is sex- dependent, mediated by T cells and sensitive to GPER activation. Cardiovasc Res. 2021 Feb 22;117(3):960-970. doi: 10.1093/cvr/cvaa075. PMID: 32215568. 20: Broughton BR, Brait VH, Kim HA, Lee S, Chu HX, Gardiner-Mann CV, Guida E, Evans MA, Miller AA, Arumugam TV, Drummond GR, Sobey CG. Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke. Stroke. 2014 Mar;45(3):835-41. doi: 10.1161/STROKEAHA.113.001499. Epub 2014 Jan 23. PMID: 24457292.