LH1753 is an Orally Bioavailable L‑Cystine Crystallization Inhibitor (IC50 = 29.5 nM) for Cystinuria. LH1753 demonstrated good oral bioavailability and in vivo efficacy in preventing L-cystine stone formation in the Slc3a1-knockout mouse model of cystinuria.
MedKoo Cat#: 127167
Name: LH1753
CAS#: N/A
Chemical Formula: C22H44Cl4N6O2S2
Exact Mass: 628.1721
Molecular Weight: 630.55
Elemental Analysis: C, 41.91; H, 7.03; Cl, 22.49; N, 13.33; O, 5.07; S, 10.17
The following data is based on the product molecular weight 630.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
