IMP-7068 | Wee1 inhibitor

MedKoo Cat#: 127165 | Name: IMP-7068

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IMP-7068 is a Wee1 inhibitor.

Chemical Structure

IMP-7068

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127165

Name: IMP-7068

CAS#: N/A

Chemical Formula: C27H27Cl2N7O

Exact Mass: 535.1654

Molecular Weight: 536.46

Elemental Analysis: C, 60.45; H, 5.07; Cl, 13.22; N, 18.28; O, 2.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IMP-7068; IMP 7068; IMP7068

IUPAC/Chemical Name

6-(2,6-dichlorophenyl)-2-((3-methyl-4-(1-methylpiperidin-4-yl)phenyl)amino)-8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one

InChi Key

FLBCTXWRHDMYSY-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H27Cl2N7O/c1-16-14-18(6-7-19(16)17-8-11-34(2)12-9-17)32-26-31-15-20-24(33-26)35-13-10-30-27(35)36(25(20)37)23-21(28)4-3-5-22(23)29/h3-7,14-15,17H,8-13H2,1-2H3,(H,31,32,33)

SMILES Code

O=C1N(C2=C(Cl)C=CC=C2Cl)C3=NCCN3C4=NC(NC5=CC=C(C6CCN(C)CC6)C(C)=C5)=NC=C41

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 536.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Matheson CJ, Backos DS, Reigan P. Targeting WEE1 Kinase in Cancer. Trends Pharmacol Sci. 2016 Oct;37(10):872-881. doi: 10.1016/j.tips.2016.06.006. Epub 2016 Jul 14. PMID: 27427153. 2: Kong A, Mehanna H. WEE1 Inhibitor: Clinical Development. Curr Oncol Rep. 2021 Jul 16;23(9):107. doi: 10.1007/s11912-021-01098-8. PMID: 34269904; PMCID: PMC8285350. 3: Ghelli Luserna di Rorà A, Cerchione C, Martinelli G, Simonetti G. A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target. J Hematol Oncol. 2020 Sep 21;13(1):126. doi: 10.1186/s13045-020-00959-2. PMID: 32958072; PMCID: PMC7507691. 4: Koh SB. The expanding role of WEE1. Cell Signal. 2022 Jun;94:110310. doi: 10.1016/j.cellsig.2022.110310. Epub 2022 Mar 16. PMID: 35304285. 5: Shi L, Xue X, Tian H, Ye H, Wang H, Wang R, Liu Y, Zhang C, Chen Q, Sun L. WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway. Reprod Biol Endocrinol. 2021 Oct 22;19(1):161. doi: 10.1186/s12958-021-00844-8. PMID: 34686198; PMCID: PMC8532311.