Hyrtiosal | CAS#138355-07-4 | PTP1B inhibitor

MedKoo Cat#: 145681 | Name: Hyrtiosal

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hyrtiosal is a protein tyrosine phosphatase 1B (PTP1B) inhibitor. HYRTIOSAL comes from the marine sponge Hyrtios erectus. HYRTIOSAL displays extensive cellular effects on PI3K/AKT activation, glucose transport, and TGFbeta/Smad2 signaling.

Chemical Structure

Hyrtiosal

CAS#138355-07-4

Theoretical Analysis

MedKoo Cat#: 145681

Name: Hyrtiosal

CAS#: 138355-07-4

Chemical Formula: C25H38O3

Exact Mass: 386.2800

Molecular Weight: 386.58

Elemental Analysis: C, 77.68; H, 9.91; O, 12.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Hyrtiosal;

IUPAC/Chemical Name

(2S,3S,3aR,5aS,9aS,9bR)-3-((S)-2-(furan-3-yl)-2-hydroxyethyl)-2,3a,6,6,9a-pentamethyldodecahydro-1H-cyclopenta[a]naphthalene-2-carbaldehyde

InChi Key

PUTJFIQGLGDLIT-RNDOZLNUSA-N

InChi Code

1S/C25H38O3/c1-22(2)9-6-10-24(4)19(22)7-11-25(5)20(23(3,16-26)14-21(24)25)13-18(27)17-8-12-28-15-17/h8,12,15-16,18-21,27H,6-7,9-11,13-14H2,1-5H3/t18-,19-,20+,21+,23+,24-,25-/m0/s1

SMILES Code

[H][C@]12C[C@](C)(C=O)[C@@H](C[C@H](O)C3=COC=C3)[C@]1(C)CC[C@@]4([H])C(C)(C)CCC[C@]24C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 386.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Du L, Shen L, Yu Z, Chen J, Guo Y, Tang Y, Shen X, Jiang H. Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site. ChemMedChem. 2008 Jan;3(1):173-80. doi: 10.1002/cmdc.200700223. PMID: 17943714. 2: Sun T, Wang Q, Yu Z, Zhang Y, Guo Y, Chen K, Shen X, Jiang H. Hyrtiosal, a PTP1B inhibitor from the marine sponge Hyrtios erectus, shows extensive cellular effects on PI3K/AKT activation, glucose transport, and TGFbeta/Smad2 signaling. Chembiochem. 2007 Jan 22;8(2):187-93. doi: 10.1002/cbic.200600349. PMID: 17183521. 3: Youssef DT, Yamaki RK, Kelly M, Scheuer PJ. Salmahyrtisol A, a novel cytotoxic sesterterpene from the Red Sea sponge Hyrtios erecta. J Nat Prod. 2002 Jan;65(1):2-6. doi: 10.1021/np0101853. PMID: 11809054.