MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 127156 | Name: Eth-1001
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ETH 1001, also known as Calcium ionophore I, is a a Ca2+ selective ionophore for biological membranes. Eth-1001 can be used in microelectrodes for the determination of intracellular Ca2+-activities and of slowly changing Ca2+ levels. ETH 1001 promoted Ca2+ flux across RBC membranes under various experimental conditions. ETH 1001 did not promote the passive movement of Mg2+.

Chemical Structure

Eth-1001
Eth-1001
CAS#58801-34-6

Theoretical Analysis

MedKoo Cat#: 127156

Name: Eth-1001

CAS#: 58801-34-6

Chemical Formula: C38H72N2O8

Exact Mass: 684.5289

Molecular Weight: 685.00

Elemental Analysis: C, 66.63; H, 10.60; N, 4.09; O, 18.68

Price and Availability

Size Price Availability Quantity
25mg USD 750.00 2 Weeks
100mg USD 2,150.00 2 Weeks
1g USD 6,950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Eth 1001; Eth-1001; Eth1001; CA 1001; CA1001; CA-1001; Calcium ionophore I; Calcium ionophore; calcium-ionophore I
IUPAC/Chemical Name
diethyl 13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontanedioate
InChi Key
CJAONIOAQZUHPN-UHFFFAOYSA-N
InChi Code
InChI=1S/C38H72N2O8/c1-7-45-37(43)27-23-19-15-11-9-13-17-21-25-29-39(5)35(41)31-47-33(3)34(4)48-32-36(42)40(6)30-26-22-18-14-10-12-16-20-24-28-38(44)46-8-2/h33-34H,7-32H2,1-6H3
SMILES Code
CCOC(=O)CCCCCCCCCCCN(C)C(=O)COC(C)C(C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC
Appearance
Liquid
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Calcium ions are crucial in numerous physiological processes, and their precise measurement is important for many clinical diagnostics and therapeutic interventions. Traditional detection methods, such as atomic absorption spectroscopy, cannot meet clinical requirements, as they measure total calcium instead of the clinically relevant ionized form (Ca2+). Ion-selective electrodes (ISEs) provide a convenient, accurate, and specific method for Ca2+ determination.

Preparing Stock Solutions

The following data is based on the product molecular weight 685.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Y, Zhou J, Yang T, Li X, Zhang Y, Huang Z, Mattos GJ, Tiuftiakov NY, Wu Y, Gao J, Qin Y, Bakker E. Complexation Behavior and Clinical Assessment of Isomeric Calcium Ionophores of ETH 1001 in Polymeric Ion-Selective Membranes. ACS Sens. 2024 Dec 27;9(12):6512-6519. doi: 10.1021/acssensors.4c01907. Epub 2024 Nov 25. PMID: 39587851. 2: Zhao F, Liu Y, Dong H, Feng S, Shi G, Lin L, Tian Y. An Electrochemophysiological Microarray for Real-Time Monitoring and Quantification of Multiple Ions in the Brain of a Freely Moving Rat. Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10426-10430. doi: 10.1002/anie.202002417. Epub 2020 Apr 15. PMID: 32190959. 3: He N, Lindfors T. Determination of water uptake of polymeric ion-selective membranes with the coulometric Karl Fischer and FT-IR-attenuated total reflection techniques. Anal Chem. 2013 Jan 15;85(2):1006-12. doi: 10.1021/ac3027838. Epub 2012 Dec 31. PMID: 23249325. 4: Lindfors T, Szücs J, Sundfors F, Gyurcsányi RE. Polyaniline nanoparticle- based solid-contact silicone rubber ion-selective electrodes for ultratrace measurements. Anal Chem. 2010 Nov 15;82(22):9425-32. doi: 10.1021/ac102099p. Epub 2010 Oct 26. PMID: 20977198. 5: Bychkova V, Shvarev A. Surface area effects on the response mechanism of ion optodes: a preliminary study. Anal Chem. 2009 Sep 1;81(17):7416-9. doi: 10.1021/ac901220d. PMID: 19655773. 6: Shim JH, Jeong IS, Lee MH, Hong HP, On JH, Kim KS, Kim HS, Kim BH, Cha GS, Nam H. Ion-selective electrodes based on molecular tweezer-type neutral carriers. Talanta. 2004 May 10;63(1):61-71. doi: 10.1016/j.talanta.2003.12.050. PMID: 18969404. 7: Aoki H, Umezawa Y, Vertova A, Rondinini S. Ion-channel sensors based on ETH 1001 ionophore embedded in charged-alkanethiol self-assembled monolayers on gold electrode surfaces. Anal Sci. 2006 Dec;22(12):1581-4. doi: 10.2116/analsci.22.1581. PMID: 17159319. 8: Liao WY, Weng CH, Lee GB, Chou TC. Development and characterization of an all-solid-state potentiometric biosensor array microfluidic device for multiple ion analysis. Lab Chip. 2006 Oct;6(10):1362-8. doi: 10.1039/b603364d. Epub 2006 Aug 14. PMID: 17102850. 9: Bedlechowicz-Sliwakowska I, Lingenfelter P, Sokalski T, Lewenstam A, Maj- Zurawska M. Ion-selective electrode for measuring low Ca2+ concentrations in the presence of high K+, Na+ and Mg2+ background. Anal Bioanal Chem. 2006 Aug;385(8):1477-82. doi: 10.1007/s00216-006-0607-y. Epub 2006 Jul 18. PMID: 16847621. 10: Takamaki A, Mori Y, Araki M, Mineharu A, Sohma Y, Tashiro J, Yoshida R, Takenaka H, Kubota T. Asphyxia and diuretic-induced changes in the Ca2+ concentration of endolymph. Jpn J Physiol. 2003 Feb;53(1):35-44. doi: 10.2170/jjphysiol.53.35. PMID: 12689356. 11: Michalska A, Konopka A, Maj-Zurawska M. All-solid-state calcium solvent polymeric membrane electrode for low-level concentration measurements. Anal Chem. 2003 Jan 1;75(1):141-4. doi: 10.1021/ac025916y. PMID: 12530830. 12: Kovács B, Nagy G, Dombi R, Tóth K. Optical biosensor for urea with improved response time. Biosens Bioelectron. 2003 Mar;18(2-3):111-8. doi: 10.1016/s0956-5663(02)00164-1. PMID: 12485757. 13: Lee MH, Yoo CL, Lee JS, Cho IS, Kim BH, Cha GS, Nam H. Tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. Anal Chem. 2002 Jun 1;74(11):2603-7. doi: 10.1021/ac011160b. PMID: 12069244. 14: Malinowska E, Meyerhoff ME. Influence of nonionic surfactants on the potentiometric response of ion-selective polymeric membrane electrodes designed for blood electrolyte measurements. Anal Chem. 1998 Apr 15;70(8):1477-88. doi: 10.1021/ac970761t. PMID: 9569759. 15: Nägele M, Mi Y, Bakker E, Pretsch E. Influence of lipophilic inert electrolytes on the selectivity of polymer membrane electrodes. Anal Chem. 1998 May 1;70(9):1686-91. doi: 10.1021/ac970903j. PMID: 21651262. 16: Mootha VK, French S, Balaban RS. Neutral carrier-based "Ca(2+)-selective" microelectrodes for the measurement of tetraphenylphosphonium. Anal Biochem. 1996 May 1;236(2):327-30. doi: 10.1006/abio.1996.0174. PMID: 8660512. 17: Oh BK, Kim CY, Lee HJ, Rho KL, Cha GS, Nam H. One-component room temperature vulcanizing-type silicone rubber-based calcium-selective electrodes. Anal Chem. 1996 Feb 1;68(3):503-8. doi: 10.1021/ac950789+. PMID: 21619086. 18: Prestipino G, Falugi C, Falchetto R, Gazzotti P. The ionophore ETH 129 as Ca2+ translocator in artificial and natural membranes. Anal Biochem. 1993 Apr;210(1):119-22. doi: 10.1006/abio.1993.1160. PMID: 8489006. 19: Kubota T, Hagiwara N, Fujimoto M. Intracellular calcium measurements with PVC-resin Ca-selective microelectrodes in frog proximal tubules and sartorius muscle fibers. Jpn J Physiol. 1990;40(1):79-95. doi: 10.2170/jjphysiol.40.79. PMID: 2362385. 20: Lücke A, Lehmenkühler A, Speckmann EJ. The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001). J Neurosci Methods. 1989 Aug;29(2):139-42. doi: 10.1016/0165-0270(89)90025-3. PMID: 2770337.7.