WMS-1405 a derivative of ifenprodil. WMS-1405 is a potent NR2B-selective NMDA receptor antagonist, exhibiting a Ki value of 5.4 nM. Synthesized from a central building block, WMS-1405 demonstrated high NR2B affinity due to the specific distance between its basic nitrogen atom and phenyl residue. WMS-1405 has potential to be an NMDA antagonist with therapeutic implications for excitotoxicity.
MedKoo Cat#: 145046
Name: WMS-1405
CAS#: 1232196-73-4
Chemical Formula: C21H27NO2
Exact Mass: 325.2042
Molecular Weight: 325.45
Elemental Analysis: C, 77.50; H, 8.36; N, 4.30; O, 9.83
The following data is based on the product molecular weight 325.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
