Octyl Orlistat | CAS#1243011-56-4 | Fatty acid synthase inhibitor

MedKoo Cat#: 145005 | Name: Octyl Orlistat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Octyl Orlistat is a potential fatty acid synthase inhibitor (FASN) according to studies that measure tumor cell viability. Inhibition of this enzyme reduces tumor cell proliferation. Orlistat is being studied to be used as an anti-tumor drug as it targets FASN and can trigger apoptosis. Orlistat was a more potent inhibitor in cell cultures and cell lines compared to Cerulenin and C75. In LN229, cell-growth was reduced by 63.9 ± 8.7 % after 48 h and 200 µM Orlistat compared to controls; in LT68, the reduction in cell growth was 76.3 ± 23.7 %. Organotypic slice cultures treated with Orlistat showed reduced proliferation after Ki67 staining and increased caspase-3 cleavage.

Chemical Structure

Octyl Orlistat

CAS#1243011-56-4

Theoretical Analysis

MedKoo Cat#: 145005

Name: Octyl Orlistat

CAS#: 1243011-56-4

Chemical Formula: C31H57NO5

Exact Mass: 523.4237

Molecular Weight: 523.80

Elemental Analysis: C, 71.08; H, 10.97; N, 2.67; O, 15.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Octyl Orlistat; N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; [(2S)-1-[(2S,3S)-3-octyl-4-oxooxetan-2-yl]tridecan-2-yl](2S)-2-formamido-4-methylpentanoate;

IUPAC/Chemical Name

1-(3-octyl-4-oxooxetan-2-yl)tridecan-2-yl formylleucinate

InChi Key

QYVBRBCSILZWFP-DZUOILHNSA-N

InChi Code

1S/C31H57NO5/c1-5-7-9-11-13-14-15-16-18-20-26(36-31(35)28(32-24-33)22-25(3)4)23-29-27(30(34)37-29)21-19-17-12-10-8-6-2/h24-29H,5-23H2,1-4H3,(H,32,33)/t26-,27-,28-,29-/m0/s1

SMILES Code

CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCCCC)OC(=O)C(CC(C)C)NC=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 523.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Grube S, Dünisch P, Freitag D, Klausnitzer M, Sakr Y, Walter J, Kalff R, Ewald C. Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis. J Neurooncol. 2014 Jun;118(2):277-287. doi: 10.1007/s11060-014-1452-z. Epub 2014 May 1. PMID: 24789255. 2: Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ, Gomis RR. FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth. Nat Commun. 2016 Apr 5;7:11199. doi: 10.1038/ncomms11199. PMID: 27045898; PMCID: PMC4822041. 3: Sadowski MC, Pouwer RH, Gunter JH, Lubik AA, Quinn RJ, Nelson CC. The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget. 2014 Oct 15;5(19):9362-81. doi: 10.18632/oncotarget.2433. PMID: 25313139; PMCID: PMC4253440.