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MedKoo Cat#: 471144 | Name: Tumulosic Acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tumulosic acid is a triterpene that has diverse biological activities.

Chemical Structure

Tumulosic Acid
Tumulosic Acid
CAS#508-24-7

Theoretical Analysis

MedKoo Cat#: 471144

Name: Tumulosic Acid

CAS#: 508-24-7

Chemical Formula: C31H50O4

Exact Mass: 486.3710

Molecular Weight: 486.74

Elemental Analysis: C, 76.50; H, 10.35; O, 13.15

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
5mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
Tumulosic Acid; Polyporenic Acid B
IUPAC/Chemical Name
(R)-2-((3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methyleneheptanoic acid
InChi Key
XADJANKGURNTIA-YEXRKOARSA-N
InChi Code
InChI=1S/C31H50O4/c1-18(2)19(3)9-10-20(27(34)35)26-23(32)17-31(8)22-11-12-24-28(4,5)25(33)14-15-29(24,6)21(22)13-16-30(26,31)7/h18,20,23-26,32-33H,3,9-17H2,1-2,4-8H3,(H,34,35)/t20-,23-,24+,25+,26+,29-,30-,31+/m1/s1
SMILES Code
C[C@]12[C@@]([C@]([C@@H](CCC(C(C)C)=C)C(O)=O)([H])[C@@H](C1)O)(CCC3=C2CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)O)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 486.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cao K, Jiang H, Zhang L, Fan C, Feng Z, Li B, Song L, Zhang Q. Effective Components and Molecular Mechanism of Biejiaruangan Capsule Against Liver Fibrosis: High-resolution Mass Spectrometry, Network Pharmacological Analysis and Experimental Verification. Comb Chem High Throughput Screen. 2024 Oct 14. doi: 10.2174/0113862073338867240930031800. Epub ahead of print. PMID: 39411945. 2: Jin R, Zhao Z, Zhang Q, Sun YU, Wang W, Peng D, Nian S, Zhou L. An anti- inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology. Pharmazie. 2024 May 15;79(3):72-81. doi: 10.1691/ph.2024.3647. PMID: 38872267. 3: Liu H, Jing N, Li F, Wang K, Tang J, Zhao Q, Zhang Y, Noushahi HA, Xu R, Wang X, Zhu W, Feng S, Shu S, Mei Z. An omics-based characterization of Wolfiporia cocos reveals three CYP450 members involved in the biosynthetic pathway of pachymic acid. Commun Biol. 2024 May 30;7(1):666. doi: 10.1038/s42003-024-06323-1. PMID: 38816492; PMCID: PMC11139888. 4: Huang S, Cai S, Ling L, Zhang W, Xiao H, Yu D, Zhong X, Tao P, Luo Y. Investigating the molecular mechanism of traditional Chinese medicine for the treatment of placental syndromes by influencing inflammatory cytokines using the Mendelian randomization and molecular docking technology. Front Endocrinol (Lausanne). 2024 Feb 1;14:1290766. doi: 10.3389/fendo.2023.1290766. PMID: 38362587; PMCID: PMC10868387. 5: Wu T, Hou W, Li S, Liu C, Zhang Y. Integrated analysis and separation of 5-lipoxygenase inhibitors from triterpenes of Poria cocos using bioaffinity ultrafiltration UPLC-Q-Exactive, molecular docking and target-based multiple complex networks. Fitoterapia. 2024 Jun;175:105856. doi: 10.1016/j.fitote.2024.105856. Epub 2024 Feb 12. PMID: 38354820. 6: Abdel-Baki PM, El-Sherei MM, Khaleel AE, Abdel-Sattar E, Salem MA, Okba MM. Correlation between secondary metabolites of Iris confusa Sealy and Iris pseudacorus L. and their newly explored antiprotozoal potentials. BMC Complement Med Ther. 2023 Dec 16;23(1):465. doi: 10.1186/s12906-023-04294-0. PMID: 38104072; PMCID: PMC10725014. 7: Li S, Sun Y, Gao Y, Yu X, Zhao C, Song X, Han F, Yu J. Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease. J Pharm Biomed Anal. 2024 Jan 5;237:115765. doi: 10.1016/j.jpba.2023.115765. Epub 2023 Oct 4. PMID: 37844366. 8: Li Z, Shi H. Study on the active ingredients of Shenghui decoction inhibiting acetylcholinesterase based on molecular docking and molecular dynamics simulation. Medicine (Baltimore). 2023 Sep 22;102(38):e34909. doi: 10.1097/MD.0000000000034909. PMID: 37746985; PMCID: PMC10519482. 9: Shu ZH, Fan CL, Wei HY, Li ZT, Norimoto H, Tang XY, Yao ZH, Yao XS, Dai Y. An integrated strategy by absorbed component characterization, pharmacokinetics, and activity evaluation for identification of potential nephroprotective substances in Zhu-Ling decoction. J Sep Sci. 2023 Sep;46(17):e2300331. doi: 10.1002/jssc.202300331. Epub 2023 Jul 12. PMID: 37438987. 10: Wu T, Hou W, Liu C, Li S, Zhang Y. Efficient Combination of Complex Chromatography, Molecular Docking and Enzyme Kinetics for Exploration of Acetylcholinesterase Inhibitors from Poria cocos. Molecules. 2023 Jan 27;28(3):1228. doi: 10.3390/molecules28031228. PMID: 36770895; PMCID: PMC9920314. 11: Wang H, Sun X, Wei C, Wang J, Xu Y, Bai G, Yao Q, Zhang L. Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents. Med Chem Res. 2023;32(2):342-354. doi: 10.1007/s00044-022-03009-3. Epub 2022 Dec 29. PMID: 36593868; PMCID: PMC9797892. 12: Takiyama M, Matsumoto T, Kaifuchi N, Mizuhara Y, Warabi E, Ohbuchi K, Mizoguchi K. In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes. Xenobiotica. 2022 May;52(5):511-519. doi: 10.1080/00498254.2022.2078750. Epub 2022 Jul 25. PMID: 35855663. 13: Guo M, Zhu F, Qiu W, Qiao G, Law BY, Yu L, Wu J, Tang Y, Yu C, Qin D, Zhou X, Wu A. High-throughput screening for amyloid-β binding natural small- molecules based on the combinational use of biolayer interferometry and UHPLC- DAD-Q/TOF-MS/MS. Acta Pharm Sin B. 2022 Apr;12(4):1723-1739. doi: 10.1016/j.apsb.2021.08.030. Epub 2021 Sep 4. PMID: 35847494; PMCID: PMC9279722. 14: Peng X, Jia C, Chi H, Wang P, Fu H, Li Y, Wang Q. Efficacy and Pharmacological Mechanism of Poria cocos-Based Formulas Combined With Chemotherapy for Ovarian Cancer: A Integrated Systems Pharmacology Study. Front Pharmacol. 2022 Mar 21;13:788810. doi: 10.3389/fphar.2022.788810. PMID: 35401186; PMCID: PMC8985862. 15: Ji B, Zhao Y, Yu P, Yang B, Zhou C, Yu Z. LC-ESI-MS/MS method for simultaneous determination of eleven bioactive compounds in rat plasma after oral administration of Ling-Gui-Zhu-Gan Decoction and its application to a pharmacokinetics study. Talanta. 2018 Dec 1;190:450-459. doi: 10.1016/j.talanta.2018.08.020. Epub 2018 Aug 6. PMID: 30172532. 16: Matsubara Y, Matsumoto T, Koseki J, Kaneko A, Aiba S, Yamasaki K. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017 Oct 27;22(11):1829. doi: 10.3390/molecules22111829. PMID: 29077044; PMCID: PMC6150226. 17: Yang PF, Liu C, Wang HQ, Li JC, Wang ZZ, Xiao W, Chen RY. [Chemical constituents of Poria cocos]. Zhongguo Zhong Yao Za Zhi. 2014 Mar;39(6):1030-3. Chinese. PMID: 24956845. 18: Lv C, Li Q, Zhang Y, Sui Z, He B, Xu H, Yin Y, Chen X, Bi K. A UFLC-MS/MS method with a switching ionization mode for simultaneous quantitation of polygalaxanthone III, four ginsenosides and tumulosic acid in rat plasma: application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats. J Mass Spectrom. 2013 Aug;48(8):904-13. doi: 10.1002/jms.3230. PMID: 23893636. 19: Cai TG, Cai Y. Triterpenes from the fungus Poria cocos and their inhibitory activity on nitric oxide production in mouse macrophages via blockade of activating protein-1 pathway. Chem Biodivers. 2011 Nov;8(11):2135-43. doi: 10.1002/cbdv.201100013. PMID: 22083926. 20: Xiao F, Li Q, Liang K, Zhao L, He B, Ji W, Chen X, Wang Z, Bi K, Jia Y. Comparative pharmacokinetics of three triterpene acids in rat plasma after oral administration of Poria extract and its formulated herbal preparation: GuiZhi- FuLing capsule. Fitoterapia. 2012 Jan;83(1):117-24. doi: 10.1016/j.fitote.2011.10.001. Epub 2011 Oct 10. PMID: 22008604.