Synonym
L-694,247 (trifluoroacetate salt); L-694,247 trifluoroacetate salt; L-694,247; L694,247
IUPAC/Chemical Name
N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]-methanesulfonamide, trifluoroacetate salt
InChi Key
UPFZBIGQSZGYJJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21N5O3S.C2HF3O2/c1-29(26,27)25-16-5-2-13(3-6-16)10-19-23-20(28-24-19)14-4-7-18-17(11-14)15(8-9-21)12-22-18;3-2(4,5)1(6)7/h2-7,11-12,22,25H,8-10,21H2,1H3;(H,6,7)
SMILES Code
CS(=O)(NC1=CC=C(CC2=NOC(C3=CC4=C(NC=C4CCN)C=C3)=N2)C=C1)=O.O=C(O)C(F)(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
525.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: De Castro-e-Silva E, Sarmento C, Nascimento TA, Luz CP, Soares T, Marinho A, Cunha M, Bulcäo C, De Oliveira IR, Fregoneze JB. Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats. Pharmacol Biochem Behav. 1997 Aug;57(4):749-54. PubMed PMID: 9259002.
2: Heald A, Stanton JA, Osborne SA, Middlemiss DN, Beer MS. [3H]L-694,247 labels the 5-HT1D beta receptor in pig caudate membranes. Eur J Pharmacol. 1994 Oct 24;264(2):213-6. PubMed PMID: 7851485.
3: Beer MS, Stanton JA, Bevan Y, Heald A, Reeve AJ, Street LJ, Matassa VG, Hargreaves RJ, Middlemiss DN. L-694,247: a potent 5-HT1D receptor agonist. Br J Pharmacol. 1993 Nov;110(3):1196-200. PubMed PMID: 8298808; PubMed Central PMCID: PMC2175804.
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