Gridegalutamide, also known as BMS-986365 and CC-94676, is a heterobifunctional, first-in-class, orally bioavailable AR LDD designed to induce rapid, sustained, and highly selective AR degradation in patients who progressed on standard-of-care therapies. AR degrader CC-94676 causes degradation of AR, prevents AR-mediated signaling and inhibits the proliferation of AR-overexpressing tumor cells. AR plays a key role in tumor cell proliferation in castration-resistant prostate cancer (CRPC).
MedKoo Cat#: 207218
Name: Gridegalutamide
CAS#: 2446928-30-7 (free base)
Chemical Formula: C41H45F3N8O5S
Exact Mass: 818.3186
Molecular Weight: 818.92
Elemental Analysis: C, 60.13; H, 5.54; F, 6.96; N, 13.68; O, 9.77; S, 3.91
The following data is based on the product molecular weight 818.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
