LBA-3 is a solute carrier 13 member 5 (SLC13A5) inhibitor for the treatment of hyperlipidemia with an IC50 value of 67 nM, significantly improving upon PF-06649298. In vitro assays demonstrated LBA-3’s efficacy in reducing triglyceride levels in OPA-induced HepG2 cells. Moreover, LBA-3 displayed superior pharmacokinetic properties and effectively lowered triglyceride and total cholesterol levels in diverse mouse models (PCN-stimulated and starvationinduced), without detectable toxicity.
MedKoo Cat#: 126694
Name: LBA-3
CAS#: N/A
Chemical Formula: C18H18O5
Exact Mass: 314.1154
Molecular Weight: 314.34
Elemental Analysis: C, 68.78; H, 5.77; O, 25.45
The following data is based on the product molecular weight 314.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
