Remetinostat, also known as SHP-141, is a topical formulation containing the histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Upon cutaneous administration, SHP-141 selectively binds to and inhibits HDAC, resulting in an accumulation of highly acetylated histones in the skin (dermis and epidermis), the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes. These events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. Topical administration of SHP-141 allows for high concentrations of this agent locally while minimizing systemic toxicity.
MedKoo Cat#: 327021
Name: Remetinostat
CAS#: 946150-57-8
Chemical Formula: C16H21NO6
Exact Mass: 323.1369
Molecular Weight: 323.35
Elemental Analysis: C, 59.43; H, 6.55; N, 4.33; O, 29.69
The following data is based on the product molecular weight 323.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
