MedKoo Cat#: 126616 | Name: 4A3-SCC-PH
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

4A3-SCC-PH is a linker-degradable ionizable lipids (LDIL). It possesses superior endosomal escape and rapid mRNA release abilities thanks to its unique GSH-responsive cone-shaped architecture.

Chemical Structure

4A3-SCC-PH
4A3-SCC-PH
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 126616

Name: 4A3-SCC-PH

CAS#: N/A

Chemical Formula: C91H171N3O16S12

Exact Mass: 1945.9308

Molecular Weight: 1948.09

Elemental Analysis: C, 56.11; H, 8.85; N, 2.16; O, 13.14; S, 19.75

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
4A3-SCC-PH; 4A3 SCC PH; 4A3-SCC PH; 4A3 SCC-PH
IUPAC/Chemical Name
((methylazanediyl)bis(propane-3,1-diyl))bis(8,14-dioxo-7,15-dioxa-3,4,18,19-tetrathia-11- azahenicosane-11,1,21-triyl) tetrakis(2-methyl-3-((2-propylheptyl)thio)propanoate)
InChi Key
DHCHNVHYAHEVOX-UHFFFAOYSA-N
InChi Code
InChI=1S/C91H171N3O16S12/c1-14-22-26-36-80(32-18-5)72-111-68-76(9)88(99)107-56-64-119-115-60-52-103-84(95)40-48-93(49-41-85(96)104-53-61-116-120-65-57-108-89(100)77(10)69-112-73-81(33-19-6)37-27-23-15-2)46-30-44-92(13)45-31-47-94(50-42-86(97)105-54-62-117-121-66-58-109-90(101)78(11)70-113-74-82(34-20-7)38-28-24-16-3)51-43-87(98)106-55-63-118-122-67-59-110-91(102)79(12)71-114-75-83(35-21-8)39-29-25-17-4/h76-83H,14-75H2,1-13H3
SMILES Code
CN(CCCN(CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCCN(CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O)CCC(OCCSSCCOC(C(C)CSCC(CCC)CCCCC)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,948.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Chen Z, Tian Y, Yang J, Wu F, Liu S, Cao W, Xu W, Hu T, Siegwart DJ, Xiong H. Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo. J Am Chem Soc. 2023 Nov 8;145(44):24302-24314. doi: 10.1021/jacs.3c09143. Epub 2023 Oct 19. PMID: 37853662.