KAA-276 HCl | CAS# 167264-26-8 (HCl) | histamine HI-receptor antagonist

MedKoo Cat#: 414204 | Name: KAA-276 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KAA-276 HCl is the salt form of KAA-276 free base, a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.

Chemical Structure

KAA-276 HCl

CAS#167264-26-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 414204

Name: KAA-276 HCl

CAS#: 167264-26-8 (HCl)

Chemical Formula: C31H37FN4O6S

Exact Mass:

Molecular Weight: 612.72

Elemental Analysis: C, 60.77; H, 6.09; F, 3.10; N, 9.14; O, 15.67; S, 5.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

167264-26-8 (HCl) 167264-16-6 (free base)

Synonym

KAA-276 HCl; KAA276; KAA 276; KAA-276

IUPAC/Chemical Name

Benzenepropanoic acid, 4-(2-(5-(1-((4-fluorophenyl)methyl)-1H-benzimidazol-2-yl)hexahydro-1,5-diazocin-1(2H)-yl)ethyl)-, sulfate (1:1)

InChi Key

DBIGVHCHHUWMLR-UHFFFAOYSA-N

InChi Code

InChI=1S/C31H35FN4O2.H2O4S/c32-27-14-11-26(12-15-27)23-36-29-6-2-1-5-28(29)33-31(36)35-20-3-18-34(19-4-21-35)22-17-25-9-7-24(8-10-25)13-16-30(37)38;1-5(2,3)4/h1-2,5-12,14-15H,3-4,13,16-23H2,(H,37,38);(H2,1,2,3,4)

SMILES Code

O=C(O)CCC1=CC=C(CCN2CCCN(C3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CCC2)C=C1.O=S(O)(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 612.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kobayashi T, Takehana Y, Shinagawa K, Tsuyuki S, Tokutake Y, Sato M, Momose D. Pharmacological characterization of a novel long-acting histamine H1 receptor antagonist, KAA-276. Biol Pharm Bull. 1998 Apr;21(4):350-5. doi: 10.1248/bpb.21.350. PMID: 9586571. 2: Kobayashi T, Takehana Y, Shinagawa K, Tsuyuki S, Tokutake Y, Sato M, Momose D. Effects of inhaled KAA-276, a selective histamine H1 receptor antagonist, on antigen- and histamine-induced bronchoconstriction in animals. Arzneimittelforschung. 1998 Aug;48(8):826-31. PMID: 9748711.