MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 207217 | Name: BLU-222

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BLU-222 is an investigational, oral, potent, and selective CDK2 inhibitor. BLU-222 has shown robust anti-tumor activity in preclinical models of CCNE-aberrant ovarian, breast and gastric cancer.

Chemical Structure

BLU-222
BLU-222
CAS#2888704-84-3

Theoretical Analysis

MedKoo Cat#: 207217

Name: BLU-222

CAS#: 2888704-84-3

Chemical Formula: C15H17F2N7O2

Exact Mass: 365.1412

Molecular Weight: 365.34

Elemental Analysis: C, 49.31; H, 4.69; F, 10.40; N, 26.84; O, 8.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
BLU-222; BLU 222; BLU222; Cirtociclibum; Cirtociclib
IUPAC/Chemical Name
1H-Pyrazolo[3,4-b]pyrazin-6-amine, N-[5-(difluoromethoxy)-1H-pyrazol-3-yl]-1-[(tetrahydro-2H-pyran-4-yl)methyl]-
InChi Key
IFJSYTKOMJJYNP-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H17F2N7O2/c16-15(17)26-13-5-11(22-23-13)20-12-7-18-10-6-19-24(14(10)21-12)8-9-1-3-25-4-2-9/h5-7,9,15H,1-4,8H2,(H2,20,21,22,23)
SMILES Code
FC(F)OC1=CC(NC2=CN=C3C(N(CC4CCOCC4)N=C3)=N2)=NN1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Cell growth regulation and proliferation is dependent on cyclins and CDKs. Cyclin E1 (CCNE1) is a cell cycle regulator that activates CDK2. A broad range of aggressive cancers overexpress cyclin E and/or harbor CCNE1 gene amplifications. Inhibition or loss of CDK2 impairs the growth of CCNE1-amplified cell lines and cyclin E overexpression represents one of several CDK4/6 inhibitor resistance mechanisms, including in hormone receptor–positive/human epidermal growth factor receptor-2–negative (HR+/HER2−) breast cancer, making CDK2 inhibition a promising novel therapeutic approach

Preparing Stock Solutions

The following data is based on the product molecular weight 365.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

View History

Dezaguanine

Dezaguanine