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MedKoo Cat#: 524957 | Name: Dezaguanine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dezaguanine is a new antipurine antimetabolite. Dezaguanine has an unusual spectrum of activity against experimental rodent tumors; its activity against transplantable rodent leukemias is only modest, but it has significant activity against transplantable rodent solid tumors, particularly mammary adenocarcinomas.

Chemical Structure

Dezaguanine
Dezaguanine
CAS#41729-52-6(Dezaguanine); 87434-82-0 (Dezaguanine mesylate)

Theoretical Analysis

MedKoo Cat#: 524957

Name: Dezaguanine

CAS#: 41729-52-6(Dezaguanine); 87434-82-0 (Dezaguanine mesylate)

Chemical Formula: C6H6N4O

Exact Mass: 150.0542

Molecular Weight: 150.14

Elemental Analysis: C, 48.00; H, 4.03; N, 37.32; O, 10.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dezaguanine; CI 908;CI-908;Dezaguanina; Dezaguanina [Spanish]; NSC 261726; UNII-9DRB973HUI.
IUPAC/Chemical Name
4H-Imidazo(4,5-c)pyridin-4-one, 6-amino-1,5-dihydro-
InChi Key
KXBCLNRMQPRVTP-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H6N4O/c7-4-1-3-5(6(11)10-4)9-2-8-3/h1-2H,(H,8,9)(H3,7,10,11)
SMILES Code
c1c2c(c(=O)[nH]c1N)nc[nH]2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 150.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Chembiochem. 2015 Oct 12;16(15):2225-36. doi: 10.1002/cbic.201500315. Epub 2015 Sep 18. PubMed PMID: 26382079. 11: Dhimitruka I, Eubank TD, Gross AC, Khramtsov VV. New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4593-6. doi: 10.1016/j.bmcl.2015.08.054. Epub 2015 Aug 21. PubMed PMID: 26320620; PubMed Central PMCID: PMC4592842. 12: Fateev IV, Kharitonova MI, Antonov KV, Konstantinova ID, Stepanenko VN, Esipov RS, Seela F, Temburnikar KW, Seley-Radtke KL, Stepchenko VA, Sokolov YA, Miroshnikov AI, Mikhailopulo IA. Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides. Chemistry. 2015 Sep 14;21(38):13401-19. doi: 10.1002/chem.201501334. Epub 2015 Jul 31. PubMed PMID: 26230190. 13: Nelp MT, Bandarian V. A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate. Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10627-9. doi: 10.1002/anie.201504505. Epub 2015 Jul 17. PubMed PMID: 26228534; PubMed Central PMCID: PMC4767005. 14: Wu MC, Lowe PT, Robinson CJ, Vincent HA, Dixon N, Leigh J, Micklefield J. Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch. J Am Chem Soc. 2015 Jul 22;137(28):9015-21. doi: 10.1021/jacs.5b03405. Epub 2015 Jul 9. PubMed PMID: 26106809. 15: Liberman JA, Suddala KC, Aytenfisu A, Chan D, Belashov IA, Salim M, Mathews DH, Spitale RC, Walter NG, Wedekind JE. Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3485-94. doi: 10.1073/pnas.1503955112. Epub 2015 Jun 23. PubMed PMID: 26106162; PubMed Central PMCID: PMC4500280. 16: Bazzi S, Novotný J, Yurenko YP, Marek R. Designing a New Class of Bases for Nucleic Acid Quadruplexes and Quadruplex-Active Ligands. Chemistry. 2015 Jun 22;21(26):9414-25. doi: 10.1002/chem.201500743. Epub 2015 Jun 1. PubMed PMID: 26032561. 17: Karnawat V, Gogia S, Balaram H, Puranik M. Differential Distortion of Purine Substrates by Human and Plasmodium falciparum Hypoxanthine-Guanine Phosphoribosyltransferase to Catalyse the Formation of Mononucleotides. Chemphyschem. 2015 Jul 20;16(10):2172-81. doi: 10.1002/cphc.201500084. Epub 2015 May 5. PubMed PMID: 25944719. 18: Karnawat V, Puranik M. Solution structures of purine base analogues 9-deazaguanine and 9-deazahypoxanthine. J Biomol Struct Dyn. 2016 Mar;34(3):640-52. doi: 10.1080/07391102.2015.1042916. Epub 2015 May 20. PubMed PMID: 25894214. 19: Fergus C, Barnes D, Alqasem MA, Kelly VP. The queuine micronutrient: charting a course from microbe to man. Nutrients. 2015 Apr 15;7(4):2897-929. doi: 10.3390/nu7042897. Review. PubMed PMID: 25884661; PubMed Central PMCID: PMC4425180. 20: Dunn MR, Larsen AC, Zahurancik WJ, Fahmi NE, Meyers M, Suo Z, Chaput JC. DNA polymerase-mediated synthesis of unbiased threose nucleic acid (TNA) polymers requires 7-deazaguanine to suppress G:G mispairing during TNA transcription. J Am Chem Soc. 2015 Apr 1;137(12):4014-7. doi: 10.1021/ja511481n. Epub 2015 Mar 20. PubMed PMID: 25785966.