APD-916 | inverse agonist | histamine H3 receptor | CAS#1021169-11-8

MedKoo Cat#: 126594 | Name: APD-916

Description:

WARNING: This product is for research use only, not for human or veterinary use.

APD-916 is a potent and selective inverse agonist of the histamine H3 receptor.

Chemical Structure

APD-916

CAS#1021169-11-8 (free base)

Theoretical Analysis

MedKoo Cat#: 126594

Name: APD-916

CAS#: 1021169-11-8 (free base)

Chemical Formula: C23H31NO3S

Exact Mass: 401.2025

Molecular Weight: 401.57

Elemental Analysis: C, 68.79; H, 7.78; N, 3.49; O, 11.95; S, 7.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1021169-72-1 (dicitrate) 1021169-11-8 (free base)

Synonym

APD-916; APD916; APD 916

IUPAC/Chemical Name

(R)-1-(2-(4'-((3-methoxypropyl)sulfonyl)-[1,1'-biphenyl]-4-yl)ethyl)-2-methylpyrrolidine

InChi Key

ADRZQEOBUFIYAZ-LJQANCHMSA-N

InChi Code

InChI=1S/C23H31NO3S/c1-19-5-3-15-24(19)16-14-20-6-8-21(9-7-20)22-10-12-23(13-11-22)28(25,26)18-4-17-27-2/h6-13,19H,3-5,14-18H2,1-2H3/t19-/m1/s1

SMILES Code

COCCCS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(CCN3CCC[C@H]3C)C=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 401.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Semple G, Santora VJ, Smith JM, Covel JA, Hayashi R, Gallardo C, Ibarra JB, Schultz JA, Park DM, Estrada SA, Hofilena BJ, Smith BM, Ren A, Suarez M, Frazer J, Edwards JE, Hart R, Hauser EK, Lorea J, Grottick AJ. Identification of biaryl sulfone derivatives as antagonists of the histamine H₃ receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916). Bioorg Med Chem Lett. 2012 Jan 1;22(1):71-5. doi: 10.1016/j.bmcl.2011.11.075. Epub 2011 Nov 30. PMID: 22172695.