M4K2281 is a potent and selective ALK2 inhibitor with IC50 = 2 nM. M4K2281 show impressive levels of potency against ALK2 in both the biochemical and cellular assays. M4K2281 exhibited moderate to high brain-to-plasma ratio. Both M4K2308 and M4K2281 show impressive levels of potency against ALK2 in both the biochemical and cellular assays.
MedKoo Cat#: 126545
Name: M4K2281
CAS#: 3034840-19-9
Chemical Formula: C27H31N3O4
Exact Mass: 461.2315
Molecular Weight: 461.56
Elemental Analysis: C, 70.26; H, 6.77; N, 9.10; O, 13.87
The following data is based on the product molecular weight 461.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
