Donafenib tosylate | CAS#1333386-17-6 | multikinase inhibitor

MedKoo Cat#: 124806 | Name: Donafenib tosylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Donafenib, also known as CM-4307, is an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases with potential anticancer acivity. Donafenib is under clinical trials in China in patients with advanced hepatocellular carcinoma (HCC).

Chemical Structure

Donafenib tosylate

CAS#1333386-17-6 (tosylate)

Theoretical Analysis

MedKoo Cat#: 124806

Name: Donafenib tosylate

CAS#: 1333386-17-6 (tosylate)

Chemical Formula: C28H21D3ClF3N4O6S

Exact Mass: 0.0000

Molecular Weight: 640.05

Elemental Analysis: C, 52.54; H, 4.25; Cl, 5.54; F, 8.90; N, 8.75; O, 15.00; S, 5.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1130115-44-4 (free base) 1333386-17-6 (tosylate)

Synonym

DONAFENIB MESILATE; DONAFENIB MESYLATE; F3C1QUT2IS; CM-4307 MESYLATE;

IUPAC/Chemical Name

2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-(methyl-d3)-, 4-methylbenzenesulfonate (1:1)

InChi Key

IVDHYUQIDRJSTI-NIIDSAIPSA-N

InChi Code

InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)/i1D3;

SMILES Code

O=C(C1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1)NC([2H])([2H])[2H].O=S(C4=CC=C(C)C=C4)(O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 640.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.