Nedizantrep, also knwon as GDC-6599, is a potent TRPA1 Antagonist with IC50 = 5.3 nM. GDC-6599 demonstrated strong target engagement in both a guinea pig cinnamaldehyde-induced cough study and an AITC-induced dermal blood flow model. The oral delivery of GDC-6599 significantly reduced skin blood flow induced by topical application of TRPA1 agonist AITC.
MedKoo Cat#: 126437
Name: Nedizantrep
CAS#: 2376824-99-4
Chemical Formula: C20H19ClN6O3
Exact Mass: 426.1207
Molecular Weight: 426.86
Elemental Analysis: C, 56.28; H, 4.49; Cl, 8.30; N, 19.69; O, 11.24
The following data is based on the product molecular weight 426.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
