dGPX4 | GPX4 inhibitor/degrader

MedKoo Cat#: 126326 | Name: dGPX4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

dGPX4 is a GPX4 inhibitor/degrader.

Chemical Structure

dGPX4

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 126326

Name: dGPX4

CAS#: N/A

Chemical Formula: C46H48Cl2N8O10S

Exact Mass: 974.2591

Molecular Weight: 975.90

Elemental Analysis: C, 56.62; H, 4.96; Cl, 7.27; N, 11.48; O, 16.39; S, 3.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

dGPX4; d-GPX4; d GPX4

IUPAC/Chemical Name

2-chloro-N-(3-chloro-4-((1-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide

InChi Key

XKGCAEZHAOGHFF-UHFFFAOYSA-N

InChi Code

InChI=1S/C46H48Cl2N8O10S/c47-27-40(58)55(42(38-10-5-25-67-38)44(60)50-16-15-30-6-2-1-3-7-30)32-11-13-37(34(48)26-32)66-29-31-28-54(53-52-31)18-20-64-22-24-65-23-21-63-19-17-49-35-9-4-8-33-41(35)46(62)56(45(33)61)36-12-14-39(57)51-43(36)59/h1-11,13,25-26,28,36,42,49H,12,14-24,27,29H2,(H,50,60)(H,51,57,59)

SMILES Code

ClC1=C(OCC2=CN(CCOCCOCCOCCNC3=C(C(N(C4CCC(NC4=O)=O)C5=O)=O)C5=CC=C3)N=N2)C=CC(N(C(C6=CC=CS6)C(NCCC7=CC=CC=C7)=O)C(CCl)=O)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 975.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Luo T, Zheng Q, Shao L, Ma T, Mao L, Wang M. Intracellular Delivery of Glutathione Peroxidase Degrader Induces Ferroptosis In Vivo. Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202206277. doi: 10.1002/anie.202206277. Epub 2022 Aug 25. PMID: 35924720.