Indolapril | CI-907 | nonsulfhydryl | angiotensin-converting enzyme | ACE | inhibitor | CAS#80876-01-3

MedKoo Cat#: 126267 | Name: Indolapril

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indolapril (CI-907) is a new orally active prodrug of nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Chemical Structure

Indolapril

CAS#80876-01-3 (free base)

Theoretical Analysis

MedKoo Cat#: 126267

Name: Indolapril

CAS#: 80876-01-3 (free base)

Chemical Formula: C24H34N2O5

Exact Mass: 430.2468

Molecular Weight: 430.55

Elemental Analysis: C, 66.95; H, 7.96; N, 6.51; O, 18.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

80828-32-6 (HCl) 80828-34-8 (diacid) 80876-01-3 (free base)

Synonym

Indolapril; CI-907; CI907; CI 907; SCH 31846; SCH-31846

IUPAC/Chemical Name

(2S,3aS,7aS)-1-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)octahydro-1H-indole-2-carboxylic acid

InChi Key

VXFJYXUZANRPDJ-MQBSTWLZSA-N

InChi Code

InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18-,19-,20-,21-/m0/s1

SMILES Code

[H][C@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 430.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Blankley CJ, Kaltenbronn JS, DeJohn DE, Werner A, Bennett LR, Bobowski G, Krolls U, Johnson DR, Pearlman WM, Hoefle ML, et al. Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids. J Med Chem. 1987 Jun;30(6):992-8. PubMed PMID: 3035180. 2: La Rocca PT, Squibb RE, Powell ML, Szot RJ, Black HE, Schwartz E. Acute and subchronic toxicity of a nonsulfhydryl angiotensin-converting enzyme inhibitor. Toxicol Appl Pharmacol. 1986 Jan;82(1):104-11. PubMed PMID: 3003964. 3: Roark WH, Tinney FJ, Cohen D, Essenburg AD, Kaplan HR. Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme. J Med Chem. 1985 Sep;28(9):1291-5. PubMed PMID: 2993618. 4: Brunner HR, Nussberger J, Waeber B. The present molecules of converting enzyme inhibitors. J Cardiovasc Pharmacol. 1985;7 Suppl 1:S2-11. Review. PubMed PMID: 2580170. 5: Ryan MJ, Boucher DM, Cohen DM, Olszewski BJ, Singer RM, Smith RD, Kaplan HR. Antihypertensive profile of the angiotensin-converting enzyme inhibitors CI-906 and CI-907. Fed Proc. 1984 Apr;43(5):1330-2. PubMed PMID: 6323224. 6: Kaplan HR, Cohen DM, Essenburg AD, Major TC, Mertz TE, Ryan MJ. CI-906 and CI-907: new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors. Fed Proc. 1984 Apr;43(5):1326-9. PubMed PMID: 6323223. 7: Ryan MJ, Boucher DM, Cohen DM, Essenburg AD, Major TC, Mertz TE, Olszewski BJ, Randolph AE, Singer RM, Kaplan HR. Antihypertensive effects of CI-907 (indolapril): a novel nonsulfhydryl angiotensin converting enzyme inhibitor. J Pharmacol Exp Ther. 1984 Feb;228(2):312-8. PubMed PMID: 6319675. 8: Baum T, Sybertz EJ, Watkins RW, Ahn HS, Nelson S, Eynon E, Vander Vliet G, Pula KK, Sabin C, Desiderio DM, Becker FT, Vemulapalli S. Antihypertensive activity of SCH 31846, a non-sulfhydryl angiotensin-converting enzyme inhibitor. J Cardiovasc Pharmacol. 1983 Jul-Aug;5(4):655-67. PubMed PMID: 6193365. 9: Sybertz EJ, Baum T, Ahn HS, Nelson S, Eynon E, Desiderio DM, Pula K, Becker F, Sabin C, Moran R, Vander Vliet G, Kastner B, Smith E. Angiotensin-converting enzyme inhibitory activity of SCH 31846, a new non-sulfhydryl inhibitor. J Cardiovasc Pharmacol. 1983 Jul-Aug;5(4):643-54. PubMed PMID: 6193364.