MedKoo Cat#: 126133 | Name: α-Synuclein Degrader 2b
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

α-Synuclein Degrader 2b is a selective α-synuclein PROTAC® Degrader (DC50 = 7.5 μM; Dmax = 89%).

Chemical Structure

α-Synuclein Degrader 2b
α-Synuclein Degrader 2b
CAS#2781922-42-5

Theoretical Analysis

MedKoo Cat#: 126133

Name: α-Synuclein Degrader 2b

CAS#: 2781922-42-5

Chemical Formula: C39H41N7O10

Exact Mass: 767.2915

Molecular Weight: 767.80

Elemental Analysis: C, 61.01; H, 5.38; N, 12.77; O, 20.84

Price and Availability

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5mg USD 750.00 2 Weeks
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Related CAS #
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Synonym
α-Synuclein Degrader 2b; Alpha Synuclein Degrader 2b; αSynuclein Degrader 2b
IUPAC/Chemical Name
2-((3-(5-(benzo[d][1,3]dioxol-5-yl)-1H-pyrazol-3-yl)phenyl)amino)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethyl)acetamide
InChi Key
IYFKRANQUJUTKF-UHFFFAOYSA-N
InChi Code
InChI=1S/C39H41N7O10/c47-34-10-8-31(37(49)43-34)46-38(50)27-5-2-6-28(36(27)39(46)51)40-11-13-52-15-17-54-18-16-53-14-12-41-35(48)22-42-26-4-1-3-24(19-26)29-21-30(45-44-29)25-7-9-32-33(20-25)56-23-55-32/h1-7,9,19-21,31,40,42H,8,10-18,22-23H2,(H,41,48)(H,44,45)(H,43,47,49)
SMILES Code
O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 767.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL