α-Muricholic acid-d4 (α-MCA-d4) is intended for use as an internal standard for the quantification of α-muricholic acid by GC- or LC-MS. α-Muricholic acid is a murine-specific primary bile acid. Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity, which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids. Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.
MedKoo Cat#: 464802
Name: α-MCA-d4
CAS#: unknown
Chemical Formula: C24H36D4O5
Exact Mass: 412.3127
Molecular Weight: 412.60
Elemental Analysis: C, 69.86; H, 10.75; O, 19.39
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 72.71 | |
| DMF:PBS (pH 7.2) (1:1) | 0.5 | 1.21 | |
| DMSO | 20.0 | 48.47 | |
| Ethanol | 20.0 | 48.47 |
The following data is based on the product molecular weight 412.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
