Synonym
Ganoderiol F; Ganoderiol-F; Ganoderiol;
IUPAC/Chemical Name
(5R,10S,13R,14R,17R)-17-((R)-7-hydroxy-6-(hydroxymethyl)hept-5-en-2-yl)-4,4,10,13,14-pentamethyl-1,2,4,5,6,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
JVGJXXNUVVQEIG-MCKXIFHVSA-N
InChi Code
InChI=1S/C30H46O3/c1-20(8-7-9-21(18-31)19-32)22-12-16-30(6)24-10-11-25-27(2,3)26(33)14-15-28(25,4)23(24)13-17-29(22,30)5/h9-10,13,20,22,25,31-32H,7-8,11-12,14-19H2,1-6H3/t20-,22-,25+,28-,29-,30+/m1/s1
SMILES Code
C[C@]1(CC[C@]2([H])[C@H](C)CC/C=C(CO)/CO)C(C3=CC[C@@]12C)=CC[C@](C(C)4C)([H])[C@@]3(CCC4=O)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
454.70
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li X, Xie Y, Peng J, Hu H, Wu Q, Yang BB. Ganoderiol F purified from
Ganoderma leucocontextum retards cell cycle progression by inhibiting
CDK4/CDK6. Cell Cycle. 2019 Nov;18(21):3030-3043. doi:
10.1080/15384101.2019.1667705. Epub 2019 Sep 22. PMID: 31544588; PMCID:
PMC6791690.
2: Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB. Ganoderiol F, a ganoderma
triterpene, induces senescence in hepatoma HepG2 cells. Life Sci. 2006 Aug
15;79(12):1129-39. doi: 10.1016/j.lfs.2006.03.027. Epub 2006 Mar 28. PMID:
16635496.
3: Wu M, Shen CE, Lin QF, Zhong JY, Zhou YF, Liu BC, Xu JH, Zhang ZQ, Li P.
Sterols and triterpenoids from Ganoderma lucidum and their reversal
activities of tumor multidrug resistance. Nat Prod Res. 2022
Mar;36(5):1396-1399. doi: 10.1080/14786419.2021.1878514. Epub 2021 Mar 10. PMID:
33691545.
4: Zhang Q, Zuo F, Nakamura N, Ma CM, Hattori M. Metabolism and pharmacokinetics
in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from
Ganoderma lucidum. J Nat Med. 2009 Jul;63(3):304-10. doi:
10.1007/s11418-009-0337-5. Epub 2009 May 1. PMID: 19407927.
5: Kohno T, Hai-Bang T, Zhu Q, Amen Y, Sakamoto S, Tanaka H, Morimoto S, Shimizu
K. Tubulin polymerization-stimulating activity of Ganoderma triterpenoids. J Nat
Med. 2017 Apr;71(2):457-462. doi: 10.1007/s11418-017-1072-y. Epub 2017 Jan 11.
PMID: 28078535.
6: el-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N,
Shimotohno K, Kawahata T, Otake T. Anti-HIV-1 and anti-HIV-1-protease substances
from Ganoderma lucidum. Phytochemistry. 1998 Nov;49(6):1651-7. doi:
10.1016/s0031-9422(98)00254-4. PMID: 9862140.
