MedKoo Cat#: 126117 | Name: ZA3-Ep10
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZA3-Ep10 is a zwitterionic amino lipid (ZAL) that is able to deliver long RNAs including Cas mRNA and sgRNA. ZAL nanoparticles delivery of sgRNA enables permanent DNA editing.

Chemical Structure

ZA3-Ep10
ZA3-Ep10
CAS#2090299-48-0

Theoretical Analysis

MedKoo Cat#: 126117

Name: ZA3-Ep10

CAS#: 2090299-48-0

Chemical Formula: C66H138N6O9S

Exact Mass: 1191.0246

Molecular Weight: 1191.92

Elemental Analysis: C, 66.51; H, 11.67; N, 7.05; O, 12.08; S, 2.69

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 850.00 2 Weeks
50mg USD 2,150.00 2 Weeks
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Related CAS #
No Data
Synonym
ZA3-Ep10; ZA3Ep10; ZA3 Ep10;
IUPAC/Chemical Name
3-[2-[3-[2-[bis[2-[bis(2-hydroxydecyl)amino]ethyl]amino]ethyl-(2-hydroxydecyl)amino]propanoylamino]ethyl-dimethylazaniumyl]propane-1-sulfonate
InChi Key
IVEIUBBMCYOZFH-UHFFFAOYSA-N
InChi Code
InChI=1S/C66H138N6O9S/c1-8-13-18-23-28-33-39-61(73)56-69(46-44-66(78)67-45-54-72(6,7)53-38-55-82(79,80)81)50-47-68(48-51-70(57-62(74)40-34-29-24-19-14-9-2)58-63(75)41-35-30-25-20-15-10-3)49-52-71(59-64(76)42-36-31-26-21-16-11-4)60-65(77)43-37-32-27-22-17-12-5/h61-65,73-77H,8-60H2,1-7H3,(H-,67,78,79,80,81)
SMILES Code
O=S(CCC[N+](C)(CCNC(CCN(CCN(CCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)CCN(CC(O)CCCCCCCC)CC(O)CCCCCCCC)CC(O)CCCCCCCC)=O)C)([O-])=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,191.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Melamed JR, Hajj KA, Chaudhary N, Strelkova D, Arral ML, Pardi N, Alameh MG, Miller JB, Farbiak L, Siegwart DJ, Weissman D, Whitehead KA. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022 Jan;341:206-214. doi: 10.1016/j.jconrel.2021.11.022. Epub 2021 Nov 18. PMID: 34801660; PMCID: PMC8905090.