Arborinine | acridines | acridone | CAS#5489-57-6

MedKoo Cat#: 126116 | Name: Arborinine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arborinine is a member of acridines. It is functionally related to an acridone.

Chemical Structure

Arborinine

CAS#5489-57-6

Theoretical Analysis

MedKoo Cat#: 126116

Name: Arborinine

CAS#: 5489-57-6

Chemical Formula: C16H15NO4

Exact Mass: 285.1001

Molecular Weight: 285.30

Elemental Analysis: C, 67.36; H, 5.30; N, 4.91; O, 22.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Arborinine; 5489-57-6; Arborinin; Arbornine; 1-hydroxy-2,3-dimethoxy-10-methylacridin-9-one

IUPAC/Chemical Name

1-hydroxy-2,3-dimethoxy-10-methylacridin-9-one

InChi Key

ATBZZQPALSPNMF-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H15NO4/c1-17-10-7-5-4-6-9(10)14(18)13-11(17)8-12(20-2)16(21-3)15(13)19/h4-8,19H,1-3H3

SMILES Code

1-hydroxy-2,3-dimethoxy-10-methylacridin-9-one

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 285.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li N, Yang L, Zuo H. Arborinine suppresses ovarian cancer development through inhibition of LSD1. Life Sci. 2022 Feb 15;291:120275. doi: 10.1016/j.lfs.2021.120275. Epub 2021 Dec 31. PMID: 34979197. 2: Feng C, Gong L, Wang J. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. doi: 10.29219/fnr.v66.8714. PMID: 36185617; PMCID: PMC9487452. 3: Chu Y, Xiao Z, Jing N, Yan W, Wang S, Ma B, Zhang J, Li Y. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. doi: 10.1007/s10637-020-01016-y. Epub 2020 Nov 19. PMID: 33215324. 4: Piboonprai K, Khumkhrong P, Khongkow M, Yata T, Ruangrungsi N, Chansriniyom C, Iempridee T. Anticancer activity of arborinine from Glycosmis parva leaf extract in human cervical cancer cells. Biochem Biophys Res Commun. 2018 Jun 12;500(4):866-872. doi: 10.1016/j.bbrc.2018.04.175. Epub 2018 May 1. PMID: 29705700. 5: Kamal LZM, Adam MAA, Shahpudin SNM, Shuib AN, Sandai R, Hassan NM, Tabana Y, Basri DF, Than LTL, Sandai D. Identification of Alkaloid Compounds Arborinine and Graveoline from Ruta angustifolia (L.) Pers for their Antifungal Potential against Isocitrate lyase (ICL1) gene of Candida albicans. Mycopathologia. 2021 May;186(2):221-236. doi: 10.1007/s11046-020-00523-z. Epub 2021 Feb 7. PMID: 33550536. 6: Réthy B, Zupkó I, Minorics R, Hohmann J, Ocsovszki I, Falkay G. Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens. Planta Med. 2007 Jan;73(1):41-8. doi: 10.1055/s-2006-951747. Epub 2006 Nov 15. PMID: 17109253. 7: Roseghini R, Falcão GM, Oliveira Costa JF, Clarêncio J, Nascimento I, Velozo E, Schaer R, Vale V, Costa SL, Costa Mde F, Tardy M, Meyer R, Menezes Freire S. The flavonoid rutin but not the alkaloid arborinine induces apoptosis in a B-cell hybridoma cell line. Planta Med. 2009 Apr;75(5):488-93. doi: 10.1055/s-0029-1185316. Epub 2009 Feb 20. PMID: 19235127.