JSF-3269 | benzothiophene antibacterial agent

MedKoo Cat#: 126074 | Name: JSF-3269

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JSF-3269 is a benzothiophene antibacterial agent. JSF-3269 was found to exhibit an enhanced profile and in vivo efficacy in an immunocompetent mouse model of acute, drug-resistant E. faecium infection.

Chemical Structure

JSF-3269

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 126074

Name: JSF-3269

CAS#: N/A

Chemical Formula: C14H7Cl2N3O5S

Exact Mass: 398.9483

Molecular Weight: 400.19

Elemental Analysis: C, 42.02; H, 1.76; Cl, 17.72; N, 10.50; O, 19.99; S, 8.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JSF-3269; JSF3269; JSF 3269

IUPAC/Chemical Name

N'-(3,6-dichlorobenzo[b]thiophene-2-carbonyl)-5-nitrofuran-2-carbohydrazide

InChi Key

PHMVXRKNBOTKIH-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H7Cl2N3O5S/c15-6-1-2-7-9(5-6)25-12(11(7)16)14(21)18-17-13(20)8-3-4-10(24-8)19(22)23/h1-5H,(H,17,20)(H,18,21)

SMILES Code

O=C(NNC(C1=CC=C([N+]([O-])=O)O1)=O)C(S2)=C(Cl)C3=C2C=C(Cl)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 400.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Gallardo-Macias R, Russo R, Sherwood M, Jaskowski M, Nasser W, Sharma P, Tuckman M, Singleton E, Ho HP, Park S, Patel JS, George A, Perlin D, Zimmerman MD, Connell N, Freundlich JS. Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection. J Med Chem. 2024 Jan 15. doi: 10.1021/acs.jmedchem.3c01846. Epub ahead of print. PMID: 38225186.