Synonym
Drazoxolon; Ganocide; Saisan; Sopracol;
IUPAC/Chemical Name
(Z)-4-(2-(2-chlorophenyl)hydrazono)-3-methylisoxazol-5(4H)-one
InChi Key
OOTHTARUZHONSW-LCYFTJDESA-N
InChi Code
InChI=1S/C10H8ClN3O2/c1-6-9(10(15)16-14-6)13-12-8-5-3-2-4-7(8)11/h2-5,12H,1H3/b13-9-
SMILES Code
O=C(ON=C/1C)C1=N/NC2=CC=CC=C2Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Drazoxolon is a lipid-soluble fungicide.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
237.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Daniel JW. The metabolism of arylazoisoxazolones by rats and dogs. Biochem J. 1969 Mar;111(5):695-702. PubMed PMID: 5783470; PubMed Central PMCID: PMC1187598.
2: Clark DG, McElligott TF. Acute and short-term toxicity of drazoxolon (4-(2-chlorophenylhydrazone)-3-methyl-5-isoxazolone). Food Cosmet Toxicol. 1969 Sep;7(5):481-91. PubMed PMID: 5351712.
3: Viñas P, Aguinaga N, Campillo N, Hernández-Córdoba M. Comparison of stir bar sorptive extraction and membrane-assisted solvent extraction for the ultra-performance liquid chromatographic determination of oxazole fungicide residues in wines and juices. J Chromatogr A. 2008 Jun 20;1194(2):178-83. doi: 10.1016/j.chroma.2008.04.039. Epub 2008 Apr 23. PubMed PMID: 18471821.
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6: Lyr H, Casperson G. Anomalous cell wall synthesis in Mucor mucedo (L.) Fres. induced by some fungicides and other compounds related to the problem of dimorphism. Z Allg Mikrobiol. 1982;22(4):245-54. PubMed PMID: 7123995.
7: Viñas P, Campillo N, Aguinaga N, Martínez-Castillo N, Hernández-Córdoba M. Solid-phase microextraction for the gas chromatography mass spectrometric determination of oxazole fungicides in malt beverages. Anal Bioanal Chem. 2008 Jun;391(4):1425-31. doi: 10.1007/s00216-008-1858-6. Epub 2008 Mar 17. PubMed PMID: 18344070.
8: Wang X, Ren Z, Wang M, Chen M, Lu A, Si W, Yang C. Design and synthesis of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone moiety as potential fungicides. Chem Cent J. 2018 Jul 17;12(1):83. doi: 10.1186/s13065-018-0452-z. PubMed PMID: 30019094; PubMed Central PMCID: PMC6049848.
