Synonym
RPR-109891; RPR 109891; RPR109891; Klerval;
IUPAC/Chemical Name
(S)-3-(2-aminoacetamido)-4-((S)-3-cyclohexyl-2-(N-ethyl-4-(piperidin-4-yl)butanamido)propanamido)-4-oxobutanoic acid
InChi Key
FUKJLYKZNWGGKO-SFTDATJTSA-N
InChi Code
InChI=1S/C26H45N5O6/c1-2-31(23(33)10-6-9-18-11-13-28-14-12-18)21(15-19-7-4-3-5-8-19)26(37)30-25(36)20(16-24(34)35)29-22(32)17-27/h18-21,28H,2-17,27H2,1H3,(H,29,32)(H,34,35)(H,30,36,37)/t20-,21-/m0/s1
SMILES Code
O=C(NC([C@H](CC(O)=O)NC(CN)=O)=O)[C@H](CC1CCCCC1)N(CC)C(CCCC2CCNCC2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
523.67
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Catella-Lawson F, Kapoor S, Moretti D, De Marco S, Vigilante GJ, Cucchiara AJ, Ramsey KE, Combe S, Rocca B, Theroux P, FitzGerald GA; AFIRME Investigators. Antagonism of the Fibrinogen Receptor after Myocardial Events. Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease. Am J Cardiol. 2001 Aug 1;88(3):236-42. PubMed PMID: 11472700.
2: Giugliano RP, McCabe CH, Sequeira RF, Frey MJ, Henry TD, Piana RN, Tamby JF, Jensen BK, Nicolas SB, Jennings LK, Wise RJ, Braunwald E. First report of an intravenous and oral glycoprotein IIb/IIIa inhibitor (RPR 109891) in patients with recent acute coronary syndromes: results of the TIMI 15A and 15B trials. Am Heart J. 2000 Jul;140(1):81-93. PubMed PMID: 10874267.
3: Weiss DJ, Mirsky ML, Evanson OA, Fagliari J, McClenahan D, McCullough B. Platelet kinetics in dogs treated with a glycoprotein IIb/IIIa peptide antagonist. Toxicol Pathol. 2000 Mar-Apr;28(2):310-6. PubMed PMID: 10805149.
