Synonym
Hesperetin triacetate; Tri-O-acetylhesperetin;
IUPAC/Chemical Name
(2S)-5,7-Bis(acetyloxy)-2-(3-(acetyloxy)-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
InChi Key
JXQZPLOAXXMSJR-SFHVURJKSA-N
InChi Code
InChI=1S/C22H20O9/c1-11(23)28-15-8-20(30-13(3)25)22-16(26)10-18(31-21(22)9-15)14-5-6-17(27-4)19(7-14)29-12(2)24/h5-9,18H,10H2,1-4H3/t18-/m0/s1
SMILES Code
COc1ccc(cc1OC(=O)C)[C@@H]2CC(=O)c3c(OC(=O)C)cc(OC(=O)C)cc3O2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
428.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang LJ, Xia S, Ma SX, Zhou SY, Zhao XQ, Wang SH, Li MY, Yang XD. Host-guest system of hesperetin and β-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability. Mater Sci Eng C Mater Biol Appl. 2016 Feb 1;59:1016-24. doi: 10.1016/j.msec.2015.10.037. Epub 2015 Oct 23. PubMed PMID: 26652460.
2: de Souza VT, de Franco ÉP, de Araújo ME, Messias MC, Priviero FB, Frankland Sawaya AC, de Oliveira Carvalho P. Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study. J Mol Recognit. 2016 Feb;29(2):80-7. doi: 10.1002/jmr.2509. Epub 2015 Sep 15. PubMed PMID: 26370929.
3: Wei L, Deng W, Cheng Z, Guo H, Wang S, Zhang X, He Y, Tang Q. Effects of hesperetin on platelet-derived growth factor-BB-induced pulmonary artery smooth muscle cell proliferation. Mol Med Rep. 2016 Jan;13(1):955-60. doi: 10.3892/mmr.2015.4625. Epub 2015 Nov 30. PubMed PMID: 26647836.
4: Shen C, Chen R, Qian Z, Huang C, Meng X, Ma T, Chen Z, Huang X, Li L, Zang H, Li J. A HPLC-MS/MS method for the quantitation of free, conjugated, and total HDND-7, a novel hesperetin derivative, in rat plasma and tissues: Application to the pharmacokinetic and tissue distribution study. J Pharm Biomed Anal. 2016 Jan 25;118:149-60. doi: 10.1016/j.jpba.2015.10.031. Epub 2015 Oct 27. PubMed PMID: 26551533.
5: Wang QQ, Shi JB, Chen C, Huang C, Tang WJ, Li J. Hesperetin derivatives: Synthesis and anti-inflammatory activity. Bioorg Med Chem Lett. 2016 Mar 1;26(5):1460-5. doi: 10.1016/j.bmcl.2016.01.058. Epub 2016 Jan 22. PubMed PMID: 26848111.
