MedKoo Cat#: 126013 | Name: DOTA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DOTA is an azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group. It has a role as a chelator and a copper chelator. It derives from a hydride of a 1,4,7,10-tetraazacyclododecane. It is a a metal chelate in use in medical diagnostics.

Chemical Structure

DOTA
DOTA
CAS#60239-18-1

Theoretical Analysis

MedKoo Cat#: 126013

Name: DOTA

CAS#: 60239-18-1

Chemical Formula: C16H28N4O8

Exact Mass: 404.1907

Molecular Weight: 404.42

Elemental Analysis: C, 47.52; H, 6.98; N, 13.85; O, 31.65

Price and Availability

Size Price Availability Quantity
500mg USD 150.00 Ready to ship
1g USD 250.00 Ready to ship
2g USD 400.00 Ready to ship
5g USD 750.00 Ready to ship
10g USD 1,150.00 2 weeks
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Related CAS #
No Data
Synonym
DOTA; Tetraxetan; Dota acid;
IUPAC/Chemical Name
2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid
InChi Key
WDLRUFUQRNWCPK-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
SMILES Code
C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O
Appearance
To be determined
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 404.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Stasiuk GJ, Long NJ. The ubiquitous DOTA and its derivatives: the impact of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid on biomedical imaging. Chem Commun (Camb). 2013 Apr 7;49(27):2732-46. doi: 10.1039/c3cc38507h. PMID: 23392443. 2: Sneddon D, Cornelissen B. Emerging chelators for nuclear imaging. Curr Opin Chem Biol. 2021 Aug;63:152-162. doi: 10.1016/j.cbpa.2021.03.001. Epub 2021 May 26. PMID: 34051509. 3: Kahnt M, Hoenke S, Fischer L, Al-Harrasi A, Csuk R. Synthesis and Cytotoxicity Evaluation of DOTA-Conjugates of Ursolic Acid. Molecules. 2019 Jun 17;24(12):2254. doi: 10.3390/molecules24122254. PMID: 31212958; PMCID: PMC6630699.