Firocoxib | CAS#189954-96-9 | COX-2 inhibitor

MedKoo Cat#: 525060 | Name: Firocoxib

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects.

Chemical Structure

Firocoxib

CAS#189954-96-9

Theoretical Analysis

MedKoo Cat#: 525060

Name: Firocoxib

CAS#: 189954-96-9

Chemical Formula: C17H20O5S

Exact Mass: 336.1031

Molecular Weight: 336.40

Elemental Analysis: C, 60.70; H, 5.99; O, 23.78; S, 9.53

Price and Availability

Size	Price	Availability
50mg	USD 250.00	2 Weeks
100mg	USD 450.00	2 Weeks
250mg	USD 750.00	2 Weeks
500mg	USD 1,250.00	2 Weeks
1g	USD 1,950.00	2 Weeks

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Related CAS #

No Data

Synonym

Firocoxib; Equioxx; Previcox; Librens; firocoxibum; ML 1785713; ML1785713; ML-1785713; NSC-758895; NSC758895; NSC 758895

IUPAC/Chemical Name

3-(Cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

InChi Key

FULAPETWGIGNMT-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3

SMILES Code

CC1(C)C(C2=CC=C(S(=O)(C)=O)C=C2)=C(OCC3CC3)C(O1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Synopsis of the pharmacokinetics, pharmacodynamics, applications, and safety of firocoxib in horses. Vet Anim Sci. 2023 Jan 11;19:100286. doi: 10.1016/j.vas.2023.100286. PMID: 36684818; PMCID: PMC9852958. 6: Kleinhenz MD, Odland C, Williams TE, Zhang Y, Fitzgerald AH, Sidhu PK, Wulf LW, Coetzee JF. Pharmacokinetics and tissue concentrations of firocoxib in sows following oral administration. J Vet Pharmacol Ther. 2020 Sep;43(5):491-498. doi: 10.1111/jvp.12864. Epub 2020 Apr 8. PMID: 32266983. 7: Phuwapattanachart P, Thengchaisri N. Analgesic efficacy of oral firocoxib in ovariohysterectomized cats. J Vet Sci. 2017 Jun 30;18(2):175-182. doi: 10.4142/jvs.2017.18.2.175. PMID: 27515266; PMCID: PMC5489464. 8: Rangel-Nava A, Ramírez-Uribe JM, Recillas-Morales S, Ibancovichi-Camarillo JA, Venebra-Muñoz A, Sánchez-Aparicio P. Pharmacological Regulation in the USA and Pharmacokinetics Parameters of Firocoxib, a Highly Selective Cox-2, by Pain Management in Horses. J Equine Vet Sci. 2019 Jun;77:36-42. doi: 10.1016/j.jevs.2019.02.007. Epub 2019 Feb 21. PMID: 31133314. 9: Stuart AK, KuKanich B, Caixeta LS, Coetzee JF, Barrell EA. Pharmacokinetics and bioavailability of oral firocoxib in adult, mixed-breed goats. J Vet Pharmacol Ther. 2019 Nov;42(6):640-646. doi: 10.1111/jvp.12795. Epub 2019 Aug 21. PMID: 31435966. 10: Bishop RC, Wilkins PA, Kemper AM, Stewart RM, McCoy AM. Effect of Firocoxib and Flunixin Meglumine on Large Colon Mural Thickness of Healthy Horses. J Equine Vet Sci. 2023 Jul;126:104562. doi: 10.1016/j.jevs.2023.104562. Epub 2023 May 11. PMID: 37172749. 11: Adhikari S, Tian J, Rustum AM. Comprehensive study on degradation profile of firocoxib and structural elucidation of its key degradation products. J Pharm Biomed Anal. 2023 Feb 5;224:115192. doi: 10.1016/j.jpba.2022.115192. Epub 2022 Nov 28. PMID: 36463770. 12: Coetzee JF, Sidhu PK, Seagen J, Schieber T, Kleinhenz K, Kleinhenz MD, Wulf LW, Cooper VL, Mazloom R, Jaberi-Douraki M, Lechtenberg K. Transmammary delivery of firocoxib to piglets reduces stress and improves average daily gain after castration, tail docking, and teeth clipping1. J Anim Sci. 2019 Jul 2;97(7):2750-2768. doi: 10.1093/jas/skz143. PMID: 31100113; PMCID: PMC6606487. 13: Stock ML, Gehring R, Barth LA, Wulf LW, Coetzee JF. Pharmacokinetics of firocoxib in preweaned calves after oral and intravenous administration. J Vet Pharmacol Ther. 2014 Oct;37(5):457-63. doi: 10.1111/jvp.12124. Epub 2014 Apr 8. PMID: 24708198. 14: Cook VL, Meyer CT, Campbell NB, Blikslager AT. Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. Am J Vet Res. 2009 Aug;70(8):992-1000. doi: 10.2460/ajvr.70.8.992. PMID: 19645580. 15: Wang L, Rustum AM. Determination of Firocoxib and Its Related Substances in Bulk Drug Substance Batches of Firocoxib by a High-Speed Reversed-Phase HPLC Method With a Short Fused-Core Biphenyl Column. J Chromatogr Sci. 2022 Dec 5:bmac095. doi: 10.1093/chromsci/bmac095. Epub ahead of print. PMID: 36469498. 16: Friso AM, Segabinazzi LGTM, Cyrino M, Correal SB, Freitas-Dell'Aqua CP, Teoro do Carmo M, Dell'Aqua JA Jr, Miró J, Papa FO, Alvarenga MA. Periovulatory administration of firocoxib did not alter ovulation rates and mitigated post- breeding inflammatory response in mares. Theriogenology. 2019 Oct 15;138:24-30. doi: 10.1016/j.theriogenology.2019.06.045. Epub 2019 Jun 29. PMID: 31280182. 17: Araújo RA, Sales NAA, Basile RC, Feringer-Junior WH, Apparício M, Ferraz GC, Queiroz-Neto A. Safety Assessment of an Oral Therapeutic Dose of Firocoxib on Healthy Horses. Vet Sci. 2023 Aug 22;10(9):531. doi: 10.3390/vetsci10090531. PMID: 37756053; PMCID: PMC10535825. 18: de Salazar Alcalá AG, Gioda L, Dehman A, Beugnet F. Assessment of the efficacy of firocoxib (Previcox®) and grapiprant (Galliprant®) in an induced model of acute arthritis in dogs. BMC Vet Res. 2019 Aug 29;15(1):309. doi: 10.1186/s12917-019-2052-0. Erratum in: BMC Vet Res. 2019 Oct 17;15(1):347. PMID: 31464629; PMCID: PMC6716846. 19: Letendre LT, Tessman RK, McClure SR, Kvaternick VJ, Fischer JB, Hanson PD. Pharmacokinetics of firocoxib after administration of multiple consecutive daily doses to horses. Am J Vet Res. 2008 Nov;69(11):1399-405. doi: 10.2460/ajvr.69.11.1399. PMID: 18980421. 20: Gardhouse S, Kleinhenz M, Hocker SE, Weeder M, Montgomery SR, Zhang Y, Porting A, Rooney T. Pharmacokinetics and ex vivo pharmacodynamics of oral firocoxib administration in New Zealand White rabbits (Oryctolagus cuniculus). Am J Vet Res. 2022 May 31;83(7):ajvr.21.11.0177. doi: 10.2460/ajvr.21.11.0177. PMID: 35930777.